Formulation and Evaluation of ocular in-Situ gelling system containing ciprofloxacin and Naproxen Sodium

Al-Juboori, Zahraa Amer; Mahdi, Zainab H.; Alhamdany, Anas Tarik

doi:10.5958/0974-360x.2021.00017.2

Cited by 10 publications

(2 citation statements)

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“…2 ml of the samples was collected from the receptor compartment at 2, 4, 6, 8, 10, and 12 h and replaced with an equivalent amount of the SLF. The analysis of drug release from the samples was conducted at a wavelength of 239.4 nm using a UV-Vis spectrophotometer [18,21,22].…”

Section: In Vitro Diffusion Studymentioning

confidence: 99%

Statistical Optimization and Evaluation of in Situ Gel for the Ocular Delivery of Cromolyn Sodium

NAYAK,

KONDEPATI,

RATHNANAND

et al. 2024

Int J App Pharm

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Objective: The study aimed to develop and optimize cromolyn sodium-based ocular in situ gel to improve the ophthalmic contact period and provide sustained drug release for treating allergic conjunctivitis. Methods: Formulations were prepared using sodium alginate and HPMC K4M (Hydroxypropyl Methylcellulose) polymers and were characterized and evaluated for viscosity, gelling time, in vitro drug release, and optimized using a factorial 32 DOE design (Version 11; Design Expert® software). The resulting cromolyn sodium-based formulation was tested for hyperemia and eye-scratching behavior in Wistar albino rats. Results: Increased polymer concentrations resulted in higher viscosity with decreased gelling time and in vitro drug release. The optimized formulation achieved a viscosity of 15.350 cps, a gelling time of 55.137 s, and sustained drug release of 92.61% over 12 h. The in vivo pharmacodynamic study of the optimized formulation showed a significant decrease in the frequency of eye-scratching behaviour (7.525) at a significance level of (**p<0.01) and hyperemia (1.125) (***p<0.001, *p<0.05) compared to negative and positive control indicating that the developed in situ formulation improved the drug's therapeutic effectiveness by extending its duration within the cul de sac. Conclusion: In light of these findings, this optimized cromolyn sodium in situ gel holds promise as a viable alternative to conventional eye drops

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Section: In Vitro Diffusion Studymentioning

confidence: 99%

Statistical Optimization and Evaluation of in Situ Gel for the Ocular Delivery of Cromolyn Sodium

NAYAK,

KONDEPATI,

RATHNANAND

et al. 2024

Int J App Pharm

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“…Similarly, alginate can form a gelled network in the presence of Ca 2+ ions in the ocular surface [117]. Al-Juboori et al developed a temperature-dependent in situ gelling system based on sodium alginate, incorporating ciprofloxacin and naproxen, which showed an enhanced retention time on the ocular surface [118]. Cellulose derivatives exhibit temperature-sensitive in situ gelling properties, with a phase transition temperature at around 35 • C, which aligns with the precorneal temperature [119,120].…”

Section: Stimuli-responsive In Situ Gelling Systemsmentioning

confidence: 99%

Polysaccharide-Based Nanogels to Overcome Mucus, Skin, Cornea, and Blood-Brain Barriers: A Review

Wang,

Viola,

Migliorini

et al. 2023

Pharmaceutics

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Nanocarriers have been extensively developed in the biomedical field to enhance the treatment of various diseases. However, to effectively deliver therapeutic agents to desired target tissues and enhance their pharmacological activity, these nanocarriers must overcome biological barriers, such as mucus gel, skin, cornea, and blood-brain barriers. Polysaccharides possess qualities such as excellent biocompatibility, biodegradability, unique biological properties, and good accessibility, making them ideal materials for constructing drug delivery carriers. Nanogels, as a novel drug delivery platform, consist of three-dimensional polymer networks at the nanoscale, offering a promising strategy for encapsulating different pharmaceutical agents, prolonging retention time, and enhancing penetration. These attractive properties offer great potential for the utilization of polysaccharide-based nanogels as drug delivery systems to overcome biological barriers. Hence, this review discusses the properties of various barriers and the associated constraints, followed by summarizing the most recent development of polysaccharide-based nanogels in drug delivery to overcome biological barriers. It is expected to provide inspiration and motivation for better design and development of polysaccharide-based drug delivery systems to enhance bioavailability and efficacy while minimizing side effects.

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Insight on updates in polysaccharides for ocular drug delivery

Chandra

Gorantla²,

Priya³

et al. 2022

Carbohydrate Polymers

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Formulation and Evaluation of ocular in-Situ gelling system containing ciprofloxacin and Naproxen Sodium

Cited by 10 publications

References 0 publications

Statistical Optimization and Evaluation of in Situ Gel for the Ocular Delivery of Cromolyn Sodium

Statistical Optimization and Evaluation of in Situ Gel for the Ocular Delivery of Cromolyn Sodium

Polysaccharide-Based Nanogels to Overcome Mucus, Skin, Cornea, and Blood-Brain Barriers: A Review

Insight on updates in polysaccharides for ocular drug delivery

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