Formulation and Evaluation of Nutraceutical Tablet Using Herbal Drurs by Direct Compression Method

Pal, Ashok; Nagaich, Upendra; Bharti, Charu; Gulati, N.

doi:10.22270/jddt.v4i2.789

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Formulation of chewable tablets of Syzygium cumini seed powder: Tablets were formulated by direct compression method [14][15][16]. Seven formulations were formulated with constant amount of seed powder and varied concentrations of excipients as shown in table 3.…”

Section: Methodsmentioning

confidence: 99%

“…Tapping was continued until no further change in volume was noted. The bulk density and tapped density were calculated using the following formula [14]: Compressibility Index: Compressibility index or Carr's index is an important measure that can be obtained from the bulk and tapped density. It is calculated by the equation, Carr's index = (Tapped density -Bulk density)/Tapped density.…”

Section: Determination Of Bulk Density and Tapped Densitymentioning

confidence: 99%

“…For a material to be more flowable it needs to be less compressible. A material having value of less than 20% has good flow properties [14].…”

Section: Determination Of Bulk Density and Tapped Densitymentioning

confidence: 99%

“…The device subjects the tablets to abrasion and shock by utilizing a plastic chamber that revolved at 25 rpm. Sample of 10 tablets, whose weight is measured previously, were dropped in the friabilator from a distance of 6 inches which was then operated for 100 revolutions and the tablets were dusted and reweighed [14]. According to USP, to pass the test, the tablet should not lose more than 1% of their weight.…”

Section: Friabilitymentioning

confidence: 99%

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Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder

Palakurthi¹,

Jakka²,

Singh³

et al. 2020

J. Drug Delivery Ther.

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Aim of this study is to develop chewable tablets of Syzygium cumini seed powder. It has been chosen to do so as there are no oral solid dosage forms of this seed powder developed so far. There are numerous health benefits and nutrient properties of this seed powder, thus it can be used as a nutraceutical. Phytochemical screening of the Syzygium cumini seed powder has been conducted and the various phyto constituents present were detected. Seven different formulations have been developed by direct compression method out of which five were optimized. All these formulations were developed with Syzygium cumini seed powder as the active ingredient and lactose, acacia, glucose, talc, magnesium stearate, hydroxy propyl methyl cellulose, sodium alginate, guar gum and stevia were used as excipients. Various evaluations tests were performed to check the stability of the chewable tablets. Fourier Transform Infrared Spectroscopy (FTIR) analysis was conducted to check the interactions among the seed powder and the excipients. Anti-bacterial activity of the chewable tablets was tested against three different species of bacteria (Escherichia coli and Bacillus subtilis) by agar diffusion method. It is concluded that the Syzygium cumini seed powder and the developed chewable tablets were active against Escherichia coli and Bacillus subtilis. Keywords: Syzygium cumini, Chewable tablet, anti-bacterial activity

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Section: Methodsmentioning

confidence: 99%

Section: Determination Of Bulk Density and Tapped Densitymentioning

confidence: 99%

“…For a material to be more flowable it needs to be less compressible. A material having value of less than 20% has good flow properties [14].…”

Section: Determination Of Bulk Density and Tapped Densitymentioning

confidence: 99%

Section: Friabilitymentioning

confidence: 99%

See 2 more Smart Citations

Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder

Palakurthi¹,

Jakka²,

Singh³

et al. 2020

J. Drug Delivery Ther.

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Formulations and challenges: a special emphasis on stability and safety evaluations

Gupta

Ghosh

2017

Developing New Functional Food and Nutraceutical Products

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A technical note: Characterization and evaluation of novel, ready to use co-processed excipient in nutraceutical herbal vitamin and amino acid formulations

Tomar¹,

Raj²

2020

GSC Biol. and Pharm. Sci.

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A tablet is composed of different excipients and drug. All excipients have different properties with applications. Excipients are used to provide bulk and help to bind API into a dosage form, excipient should be inert in nature with respectable physical properties. Because the physical properties play a very important role during tablet compaction. However, maximum individual excipients do not have enough physical properties especially flowability. To fulfil these requirements co-processed excipient have been starting to use in formulation industries to make tablet and capsules. All co-processes excipients have superior flowability and other physical properties and now co-processed excipients have made their own place in pharma industries. BARETab® Nutra is also a co-processed excipient, but it is a ready to use premix for direct compressible tablet and contains four different excipients like binder, glidant, disintegrant and lubricant .This study is aimed at making herbal extracts, vitamins and non-essential amino acids tablet, using BARETab® Nutra by direct compression method and evaluate in-vitro parameters like hardness, friability, disintegration time and drug released profile. Ready to use premix BARETab® Nutra delivers good tableting parameters in herbal tablet Glucosamine, vitamin tablet Pyridoxine hydrochloride and non-essential amino acid Cysteine tablet like as higher tablet hardness, less friability, less disintegration time and uniform tablet weight. All tablets carried equal amount of drug which is proved by dissolution test.

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Formulation and Evaluation of Nutraceutical Tablet Using Herbal Drurs by Direct Compression Method

Cited by 5 publications

References 7 publications

Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder

Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder

Formulations and challenges: a special emphasis on stability and safety evaluations

A technical note: Characterization and evaluation of novel, ready to use co-processed excipient in nutraceutical herbal vitamin and amino acid formulations

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