Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend

Abstract

Collagen is essential as a physiological material in wound healing, so it is often used in wound management, mainly as a lyophilisate. Collagen also has excellent film-forming properties; unfortunately, however, its utilisation as a film wound dressing is limited because of its weak mechanical properties, especially in its wet state. For this reason, modifications or combinations with different materials are investigated. The combination of collagen with partially modified microfibrillar carboxymethylcellulose (CMC), which has not previously been described, provided a new possibility for strengthening collagen films and was the aim of this work. The collagen–CMC films based on three types of collagens, two plasticizers and two collagen. Plasticiser ratios were prepared using the solvent casting method; partially modified CMC served here as both a film-forming agent and a filler, without compromising the transparency of the films. The presence of microfibrils was confirmed microscopically by SEM. Organoleptic and physicochemical evaluation, especially in terms of practical application on wounds, demonstrated that all the samples had satisfactory properties for this purpose even after wetting. All the films retained acidic pH values even after 24 h, with a maximum of 6.27 ± 0.17, and showed a mild degree of swelling, with a maximum of about 6 after 24 h.

Design and evaluation of sodium alginate-based hydrogel dressings containing Betula utilis extract for cutaneous wound healing

“…In comparison to traditional dressings, film-based dressings are flexible, transparent, and adhesive ( Mahmood et al, 2021 ; Tenorová et al, 2022 ). Although they cannot absorb fluid, they are able to ‘breathe off’ small amounts of fluid by moisture vapor transpiration ( Yazdanpanah et al, 2015 ).…”

The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery

“…Indeed, dermal delivery, especially for wound healing applications as well as fungal, bacterial and allergic infections, is more efficient than the per os drug administration [ 7 , 8 ]. Various research has demonstrated that topical delivery vehicles such as ointments (creams, gels, pastes) [ 9 ], sponges [ 3 ], foams [ 10 ], films [ 11 ] and membranes [ 12 , 13 , 14 ] present more advantages than disadvantages. More specifically, dermal drug delivery offers rapid medication delivery to the needed site of action, improved local bioavailability as well as patient compliance.…”

Keratose Self-Cross-Linked Wound Dressing for Iron Sequestration in Chronic Wounds

“…Several materials such as films, gauze, hydrogels, hydrocolloids, and alginates, as well as silver-based dressing have been used. Several techniques have been applied for this purpose, such as film-casting, electrospinning, freeze-drying, salt leaching, and emulsion based on synthetic macromolecules or the material of natural origin. − …”

“…Several techniques have been applied for this purpose, such as film-casting, electrospinning, freeze-drying, salt leaching, and emulsion based on synthetic macromolecules or the material of natural origin. 24 − 27 …”