Formulation and Evaluation of Novel Bilayer Floating and Sustained Release Drug Delivery System of Diltiazem HCl

Varasteghan, Hoda; Shokri, Javad; Asnaashari, Solmaz; Javadzadeh, Yousef

doi:10.21767/0975-9344.1000127

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“…Metabolism of the drug in human and animal bodies is still being studied [28]. Simpler and effective drug delivery systems can be explored with thorough investigation on metabolism [29]. Oral drug delivery faces challenges in terms of effectiveness, cost, side effects and formulation [30].…”

Section: Discussionmentioning

confidence: 99%

Drug Delivery and Hydrotropism

2020

International Journal of Advanced Research in Chemical Science

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INTRODUCTION Biotechnology and Drug Delivery SystemBiotechnology is one of the important domains in chemical engineering. As they say, the best processing plant possible is our body system. Almost all the mechanical operations, Reactions (biochemical), separations, downstream processing occur in our body system. Kinetics of biological reactions, enzyme kinetics, gene therapy, recombinant technology, drug delivery are some of the topics in biotechnology. Also, for chemical engineering courses, biotechnology is one of the electives in final year students in India in many universities. It is natural for a chemical engineer to take interest in biotechnology. Drug delivery systems play major role in the utilization of drugs. The mode of injection of the drug plays a major role is deciding ease of drug delivery. For the pharmaceutical compounds, it is very important to have proper drug delivery system which will keep their effect intact during the transportation in side our body [1][2][3][4]. THE MECHANISMThe concentration of the drug inside the body needs to be maintained above certain value to get effect out of the drug. For this purpose, the drug intake is given three to four times a day to the patient. The ability of the person to follow the drug intake schedule and the severity of the drug requirement decides mode of drug delivery which in turn has major role to play in drug transportation. Whenever drug is injected in the bodies, it spreads across various parts of bodies. Its presence is normally undesired in all parts of body. Many investigations are reported on the localized and specific drug delivery systems. In any case, this aspect reduces the amount of drug required also. Localized and specific drug delivery has advantages such as fast and rapid effects and immediate and fast relief for the patient. Diffusion plays very important role in drug delivery. Many time affinities-based mechanisms are used. The concept of hydrotropism plays very significant role in drug delivery [5][6][7][8]. Solubility of a DrugThe solubility of the compound in the solvent plays important role in utilization of the compound for drug delivery. Many common drugs are injected into body by oral route through gastrointestinal Abstract: Drug delivery systems play major role in the utilization of drugs. The mode of injection of the drug plays a major role is deciding ease of drug delivery. For the pharmaceutical compounds, it is very important to have proper drug delivery system which will keep their effect intact during the transportation in side our body. The concentration of the drug inside the body needs to be maintained above certain value to get effect out of the drug. For this purpose, the drug intake is given three to four times a day to the patient. The ability of the person to follow the drug intake schedule and the severity of the drug requirement decides mode of drug delivery which in turn has major role to play in drug transportation. The solubility of the compound in the solvent plays important role in utilization of the co...

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Section: Discussionmentioning

confidence: 99%

Drug Delivery and Hydrotropism

2020

International Journal of Advanced Research in Chemical Science

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Formulation and Evaluation of Novel Bilayer Floating and Sustained Release Drug Delivery System of Diltiazem HCl

Abstract: In te rnation a l J o u rn al of D ru g D e ve lopm e n t a n d Resear c h In e e n n t t

Cited by 1 publication

References 6 publications

Drug Delivery and Hydrotropism

Drug Delivery and Hydrotropism

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