Formulation and evaluation of novel reverse microemulsions containing salmon calcitonin in hydrofluoroalkane propellants

Shan, Ziyun; Tan, Yinhe; Qin, Lingzhen; Li, Ge; Pan, Xin; Wang, Zhouhua; Xiu, Yu; Wang, Qinruo; Wu, Chuanbin

doi:10.1016/j.ijpharm.2014.03.032

Cited by 15 publications

(15 citation statements)

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“…M n (Da) mPEG-P(LA-co-CL) 6400 mPEG-P(LA-co-CL)-COOH 6500 mPEG-P(LA-co-CL)-PEI 8300 can be found caused by the light scattering of the colloidal particles. This ''Tyndall effect'' 46,47 approved that the REDV-NP micelles have been formed by self-assembly of mPEG-P(LA-co-CL)-PEI-REDV block copolymers. The zeta potential of NP was 18.8 AE 6.6 mV (Fig.…”

Section: Samplesmentioning

confidence: 99%

Targeting REDV peptide functionalized polycationic gene carrier for enhancing the transfection and migration capability of human endothelial cells

et al. 2015

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Section: Samplesmentioning

confidence: 99%

Targeting REDV peptide functionalized polycationic gene carrier for enhancing the transfection and migration capability of human endothelial cells

et al. 2015

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“…It is not advisable to attempt to dissolve peptide drugs in propellant because the poor solubility of peptide drugs in propellant will bring in extra sedimentation instability issue. On the basis of such principles, several nanoparticulate systems were established, among which polymeric particulate carrier (Sharma et al, 2012 ) and microemulsion (Shan et al, 2014 ) are most intensively studied. In these systems, polymer or emulsifier served as a steric barrier between peptide drugs and propellant, while uniform nano-metered particle sizes assured dynamical stability.…”

Section: Introductionmentioning

confidence: 99%

Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

Huang

Yang

et al. 2017

Drug Delivery

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The objective of this study was to develop a novel anhydrous reverse micelle nanoparticles (ARM-NPs) system to overcome the sedimentation instability of peptide-containing pressurized metered-dose inhalers (pMDIs). A bottom-up method was utilized to fabricate ARM-NPs. Tertiary butyl alcohol (TBA)/water system, freeze-drying and lipid inversion method were successively used to produce the ARM-NPs for pMDI. Various characteristics of ARM-NPs were investigated including particle size, morphology, secondary structure of the peptide drug, aerosolization properties and storage stability. As revealed by the results, ARM-NPs with spherical shape possessed 147.7 ± 2.0 nm of particle size with 0.152 ± 0.021 PdI. The ARM-NPs for pMDI had satisfactory fine particle fraction (FPF) value of 46.99 ± 1.33%, while the secondary structure of the peptide drug was unchanged. Stability tests showed no pronounced sedimentation instability for over 12 weeks at 4-6 °C. Furthermore, a hypothesis was raised to explain the formation mechanism of ARM-NPs, which was verified by the differential scanning calorimetry analysis. The lecithin employed in the reverse micelle vesicles could serve as a steric barrier between peptide drugs and bulk propellant, which prevented the instability of peptide drugs in hydrophobic environment. Homogenous particle size could avoid Ostwald ripening phenomenon of particles in pMDIs. It was concluded that the ARM-NPs for pMDI could successfully overcome sedimentation instability by the steric barrier effect and homogeneous particle size.

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“…SBS swelling process was described as follows: at room temperature, the SBS toluene solution was prepared in the wide mouth bottle with the mass ratio (toluene:SBS, T/S) of 3.5 : 1, 3.0 : 1, 2.5 : 1, 2.0 : 1, and 1.5 : 1, sealed and preserved (preventing toluene volatilization), and swelled for 24 h. During this period, the swelling status is continuously observed, and the swelling of the SBS in toluene was observed by the Tyndall effect. e called Tyndall effect is an optical phenomenon that when a light beam passes through a colloid, the suspended particles in the path will scatter the light, enabling a beam of light to become visible [14,15]. is effect makes it possible the qualitative comparison of dispersion stability for SBS solution due to its colloidal nature.…”

Section: Swelling Of Sbs In Toluenementioning

confidence: 99%

Preparation and Performance Assessment of Asphalt Emulsion Modified by the Fabricated SBS Latex

Liang

Gao

et al. 2020

Advances in Civil Engineering

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Polymer modified asphalt emulsion (PMAE) has recently been proven to be one of the most effective methods to overcome the common distress of asphalt surface treatments, such as abrasion, rutting, ravelling, and poor durability. Because of the limited research studies about the preparation of PMAE using SBS latex, a new method to prepare SBS latex was developed and the feasibility of using it in preparing SBS latex modified asphalt emulsion (SBS-LMAE) was verified in this study. The optimized swelling parameters for linear SBS solutions were swelling 24 h at the temperature of 50°C with the toluene/SBS (T/S) mass ratios of 2.5 : 1 to 2.0 : 1 which was determined according to the analysis of viscosity and Tyndall effect. After that, the SBS latex with favorable dispersivity and stability was successfully fabricated with the T/S ratio of 2.0 : 1. At last, the well-specified SBS-LMAE was prepared using the fabricated latex and tested for its conventional performances and microstructure. The results show that the SBS-LMAE samples all meet the main requirements of PMAE for microsurfacing and possess appropriate uniformity and stability.

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Formulation and evaluation of novel reverse microemulsions containing salmon calcitonin in hydrofluoroalkane propellants

Cited by 15 publications

References 50 publications

Targeting REDV peptide functionalized polycationic gene carrier for enhancing the transfection and migration capability of human endothelial cells

Targeting REDV peptide functionalized polycationic gene carrier for enhancing the transfection and migration capability of human endothelial cells

Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

Preparation and Performance Assessment of Asphalt Emulsion Modified by the Fabricated SBS Latex

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