Formulation and Evaluation of Nanosuspension of Mebendazole for Solubility Enhancement by High Pressure Homogenization Technique
Abhijit Patil,
Gangotri Yadav,
Bhushan Rane
et al.
Abstract:Background: Developing and evaluating a drug taken by mouth delivery method with mebendazole nanosuspension to treat intestinal worms infestations are the main objectives of the current research effort. This is because drug particles in the nano range help to reduce particle size and enhance dissolution.
Methods: By using High pressure homogenization method, the mebendazole is converted into nanosuspension. Various amounts of HPMC K4M used as a stabilizer and Tween 80 and Poloxamer 188 used as a surfactant and… Show more
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