Formulation and evaluation of mucoadhesive buccal tablet of Anastrozole

Mohammed, Malek M.; Sadeq, Zainab Ahmed; Salih, Omar Saeb

doi:10.51847/lempsyvsbx

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…When the ex vivo mucoadhesion test was used to distinguish between the selected three sponges, the S2 sponge (κc/HPMC K4M) showed a low mucoadhesion force value of 0.04 ± 0.01 N. This could be explained by the lower hydration and swelling properties of HPMC K4M owing to its low viscosity grade (Mohammed et al., 2022 ). Therefore, S6 (κc/XG) and S9 (κc/HPMC K15M) were found to be good candidates for subsequent drug loading in S10, and S12 sponge formulations.…”

Section: Resultsmentioning

confidence: 99%

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Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions

Elbanna,

Ebada,

Abdallah

et al. 2023

Drug Delivery

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Oral cancer is one of the leading causes of death worldwide. Oral precancerous lesions (OPL) are the precursors of oral cancer, with varying degrees of progression. Tetrahydrocurcumin (THC) is a major metabolite of curcumin with superior anticancer properties against various types of cancer. However, THC’s clinical outcome is limited by its poor aqueous solubility. Herein, we developed novel mucoadhesive biopolymer-based composite sponges for buccal delivery of THC, exploiting nanotechnology and mucoadhesion for efficient prevention and treatment of oral cancer. Firstly, THC-nanocrystals (THC-NC) were formulated and characterized for subsequent loading into mucoadhesive composite sponges. The anticancer activity of THC-NC was assessed on a human tongue squamous carcinoma cell line (SCC-4). Finally, the chemopreventive activity of THC-NC loaded sponges (THC-NC-S) was examined in DMBA-induced hamster OPL. The selected THC-NC exhibited a particle size of 532.68 ± 13.20 nm and a zeta potential of −46.08 ± 1.12 mV. Moreover, THC-NC enhanced the anticancer effect against SCC-4 with an IC50 value of 80 µg/mL. THC-NC-S exhibited good mucoadhesion properties (0.24 ± 0.02 N) with sustained drug release, where 90% of THC was released over 4 days. Furthermore, THC-NC-S had a magnificent potential for maintaining high chemopreventive activity, as demonstrated by significant regression in the dysplasia degree and a decline in cyclin D1 (control: 40.4 ± 12.5, THC-NC-S: 12.07 ± 5.2), culminating in significant amelioration after 25 days of treatment. Conclusively, novel THC-NC-S represent a promising platform for local therapy of OPL, preventing their malignant transformation into cancer.

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Section: Resultsmentioning

confidence: 99%

“…Mucoadhesive properties of the selected plain sponges and THC-NC-S to fresh chicken pouch membrane were tested using the texture analyzer CT3 (Brookfield, Middleboro, USA) equipped with a 5 kg load cell (Mohammed et al., 2022 ; Pérez Zamora et al., 2022 ). The sponge was attached to the cylindrical probe using double-sided adhesive tape.…”

Section: Methodsmentioning

confidence: 99%

Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions

Elbanna,

Ebada,

Abdallah

et al. 2023

Drug Delivery

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show abstract

“…The systemic administration of medications can be avoided by using the parenteral, mucosal, or transdermal routes instead of the liver's first-pass metabolism. [2][3][4] If a drug delivery device is mucoadhesive, it can be used to keep drug in touch with the oral mucosa for an extended period of time due to the thin coating of mucin that covers its surface. Because of its close…”

Section: Introductionmentioning

confidence: 99%

Formulation Development of Mucoadhesive Tablets for Treatment of Hypertension using Losartan Potassium

Chavan,

Devineni,

Dev

et al. 2023

IJDDT

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Controlled-release losartan potassium incorporated bucccoadhesive tablets were prepared using guar gum and hydroxy propyl methylcellulose K4M (HPMC K4M). The polymers had demonstrated considerable influence for all reactions. Ethylcellulose, a naturally impermeable material, was employed as a backing layer. The direct compression approach was used to create nine distinct losartan potassium formulations. Drug and polymer compatibility was determined through preformulation research utilizing fourier transform infrared (FTIR) spectroscopy. Buccoadhesive tablets were evaluated by swelling, bioadhesive characteristics, pH and in-vitro drug dissolution. The bioadhesive strength of guar gum was found to be greater than that of HPMC K4M. The swelling effect provided by both polymers was adequate. All formulations were judged to have an adequate surface pH, with values falling between 7 and 5, suggesting no discomfort to the buccal cavity. Ex-vivo residence times ranging from 7.2 to >10 hours for all tablets tested demonstrated a high degree of adhesion. The improved formulation follows Fickian diffusion release process. The optimized formulation underwent a stability investigation in accordance with International Council for Harmonisation (ICH) criteria, and no significant changes were found.

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Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine hydrochloride by bypassing the first-pass metabolism

Arpa,

Okur,

Gök

et al. 2024

Journal of Drug Delivery Science and Technology

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Formulation and evaluation of mucoadhesive buccal tablet of Anastrozole

Cited by 6 publications

References 23 publications

Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions

Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions

Formulation Development of Mucoadhesive Tablets for Treatment of Hypertension using Losartan Potassium

Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine hydrochloride by bypassing the first-pass metabolism

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