Formulation and evaluation of mucoadhesive glipizide films

Abstract

Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl cellulose and polyethylene glycol 400 (PEG 400). Properties of the mucoadhesive film such as tensile strength, percentage elongation, swelling index, moisture content, pH and viscosity of polymeric dispersion, film thickness, content uniformity and mucoadhesion in a simulated gastric environment were characterized. In addition, percentage drug retained in stomach mucosa was estimated using a simulated dynamic stomach system as a function of time. Increase in hydroxypropyl cellulose concentration resulted in a higher tensile strength and elongation at break, while increase in concentration of PEG 400 was reflected in a decrease in tensile strength and increase of elongation at break. Glipizide/hydroxypropyl cellulose/PEG 400 (2.5:1:0.5) (GF5) was found to be the optimal composition for a novel mucoadhesive stomach formulation that showed good peelability, relatively high swelling index, moderate tensile strength, and stayed on rat stomach mucosa up to 8 h. In vivo testing of the mucoadhesive films with glipizide demonstrated a potential hypoglycemic effect.

Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

“…The increase of PG concentration led to significant decrease in the swelling index which can be attributed to the interaction of PG with the hydrophilic polymers (HPMC and PVA) via hydrogen bonding and this decreases the effective water uptake by the polymers, thus reducing the swelling of the films (Sanyang et al., 2016 ). Decrease in swelling due to the increase in the plasticizer concentration was reported in previous studies (Müller et al., 2008 ; Rajput et al., 2011 ).…”

“…It was observed that increasing the concentration of PG from 10% to 30% led to decrease in mucoadhesion force of the prepared films (Rajput et al., 2011 ) which can be explained that PG contain hydroxyl (OH) groups that can form effective hydrogen bonding with both mucin and hydrophilic polymers such as HPMC and PVA, thus weakening the effective bonding between the polymer and mucin with the consequent decrease in mucoadhesion (Rajput et al., 2011 ).…”

Formulation, Optimization, and In-Vitro Evaluation of Hyaluronic Acid Buccal Films Containing Benzydamine Hydrochloride

“…The ratio of increased length of the film to original length is calculated for elongation at break. Using a higher concentration of plasticizer resulted in lower tensile strength values, which is compatible with literature (20). Hydrophilicity and wettability of the films were evaluated by contact angle measurements.…”

Enhanced gastrointestinal survivability of recombinant Lactococcus lactis using a double coated mucoadhesive film approach

“…The addition of Lycoat RS720 polymer to both 3% and 4% sodium alginate does not result in an increase of mucoadhesion strength ( p ≥ 0.05) (S3 Table). Previous studies have reported an optimum mucoadhesive strength of 0.39±0.01 N which is close to the mucoadhesive strength of the F15 formulation (Table 3) [12]. Interestingly, addition of Lycoat RS720 also demonstrated a significant increase in percentage of elongation in both 3% and 4% sodium alginate formulations where p-value less than 0.05 (S3 Table).…”