Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac

Koirala, Santosh; Nepal, Prabin; Ghimire, Govinda; Basnet, Rojina; Rawat, Ishwori; Dahal, Aashma; Pandey, Jitendra; Parajuli-Baral, Kalpana

doi:10.1016/j.heliyon.2021.e06439

Cited by 29 publications

(30 citation statements)

References 21 publications

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“…(2) Method Validation. e validity of the method used for quantitative analysis of ketoconazole ointment formulation was confirmed by analyzing different parameters, namely linearity, limit of detection and quantification (LODs and LOQs), precision (intraday and interday variation and repeatability), and accuracy (recovery) according to ICH guideline [22] and previous study [23][24][25].…”

Section: Determination Of the Active Ingredient In The Formulationmentioning

confidence: 99%

Physicochemical Evaluation of Diploknema butyracea Seed Extract and Formulation of Ketoconazole Ointment by Using the Fat as a Base

Pandey

Khanal

Bhandari

et al. 2021

Journal of Food Quality

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The fat obtained from the ripened seeds of Diploknema butyracea is widely used as a vegetable oil in rural areas of Nepal. This study was aimed for the physicochemical evaluation (acid value, iodine value, saponification value, peroxide value, ester value, pH, and liquefaction point) of the Diploknema butyracea seed extract (chyuri fat) and the formulation of 2% w/w ketoconazole ointment by using it as a base. All the physicochemical parameters were determined quantitatively by using the method of Indian Pharmacopoeia (IP), volume-I. By fusion method, 3 different formulations F-A, F-B, and F-C were prepared, in which different proportions of chyuri fat, polyethylene glycol 6000 (PEG 600), Tween 80, and propylene glycol were used as an ointment base. Various quality parameters such as spreadability, extrudability, viscosity, smoothness, pH, average fill weight, assay, content uniformity, accelerated stability, and drug release profiles were determined. HPLC was used for the determination of ketoconazole content in the ointment formulations. Physicochemical evaluation of the chyuri fat ensured its suitability for industrial purpose. The active ingredient release profile of formulations F-A (87.71%), F-B (88.89%), and F-C (91.09%) after 5 hours were within acceptable range along with other parameters. Assay of the formulations F-A, F-B, and F-C were reported to be 103.01, 107.9, and 102.45%, respectively. Overall, evaluation of the formulation F-A, prepared by using chyrui fat only, gave satisfactory results and most of the parameters were statistically similar ( p > 0.05 ) to the F-B and F-C formulated by incorporating a certain proportion of synthetic base. Thus it can be concluded that chyuri fat can be the best alternative to replace the expensive synthetic base.

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Section: Determination Of the Active Ingredient In The Formulationmentioning

confidence: 99%

Physicochemical Evaluation of Diploknema butyracea Seed Extract and Formulation of Ketoconazole Ointment by Using the Fat as a Base

Pandey

Khanal

Bhandari

et al. 2021

Journal of Food Quality

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“…The procedure consisted of spreading a sample (drug alone or the mixture of drug and all excipients) in potassium bromide and compressed into discs by applying a pressure of 5 tons for 5 min in a hydraulic press. The pellet was kept in the light path, and the spectrum was achieved [ 2 ].…”

Section: Methodsmentioning

confidence: 99%

“…It is a convenient route for systemic effects as it enables easy ingestion, self-medication, accurate dosage, and patient compliance [ 1 ]. A major disadvantage of solid dosage forms is the difficulty in swallowing (dysphagia) or chewing in some patients (especially for geriatric and pediatric patients), gastrointestinal enzymatic degradation, and slow onset of action [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Sometimes, we have to add more amounts of some excipients (those excipients that can improve flow properties) than expected. While formulating tablets, if we use such type of single excipients that have multiple desirable properties, such as superior compressibility [ 2 ], better flow property [ 5 ], rapid disintegration capacity [ 3 ], taste-masking effect [ 4 ], and less moisture sensitivity [ 7 ], which are required for the quality formulation, then it will help to decrease the bulk of tablet, and it will have better pharmaceutical acceptability. Thus, nowadays, among different approaches, the preparation of coprocessed superdisintegrants is a popular technique [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters

Dhakal

Thakur

Mahato

et al. 2022

The Scientific World Journal

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Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity. This project was aimed to formulate and characterize orodispersible tablets of ebastine, utilizing different proportions of three disintegrants, namely crospovidone, sodium starch glycolate, and coprocessed superdisintegrant. Initially, fifteen trial batches of ebastine orodispersible tablets were outlined using the central composite design of Minitab software. The tablets were formulated by the direct compression method. The compressed tablets were then evaluated for precompression and postcompression physicochemical parameters, such as angle of repose, Carr’s index, Hausner’s ratio, hardness, thickness, weight variation, drug content, friability, wetting time, disintegration time, dispersion time, and water absorption ratio. The in vitro dissolution test was conducted according to Indian Pharmacopeia 2018, with the help of the rotating paddle method using 0.5% w/v sodium lauryl sulfate buffer in 0.1 N HCl. For the optimized batch (8th batch), all the physicochemical parameters like angle of repose (33.77°), Carr’s index (19.34%), Hausner’s ratio (1.24), weight variation (202.5 mg), hardness (4.3 kg/cm2), friability (0.44%), thickness (3.16 mm), dissolution (95.78%), and drug content (101.67%) were within the acceptable limit as per Indian Pharmacopeia 2018. The wetting time, disintegration time, dispersion time, and water absorption ratio were reported to be 25.1 seconds, 16.0 seconds, 38.6 seconds, and 91.92%, respectively. Hence, the results suggested that orodispersible tablets of ebastine can be formulated. Furthermore, the mixing of crospovidone, sodium starch glycolate, and coprocessed super disintegrants can result in excellent desirable properties in the orodispersible tablet.

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“…Aqueous binders are added as foam agent which increases surface area of foam and enhance the diffusion occurs at the water in powder bed 10 .…”

Section: Foam Granulationmentioning

confidence: 99%

Design, Development and Evaluation of Matrix Tablet

Chatterjee¹,

Sharma²,

Mishra³

2021

JBPR

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Recently, sustained release formulations have become a very helpful tool in medical practice, providing patients with a variety of benefits. Sustained release is also a potential method for reducing pharmacological side effects by preventing fluctuations in the concentration of the drug in the plasma. Nowadays, relatively few pharmaceuticals are emerging from research and development, and current drugs are suffering from resistance as a result of their inappropriate usage. Thus, altering the operation is an appropriate and optimum method of increasing the effectiveness of a medicine by a little variation in the drug distribution. The release of the medication through such a system is regulated by both dissolution and diffusion processes. Most medications, if not correctly designed, may quickly release the drug at a higher pace, resulting in hazardous concentrations of the drug upon oral administration. This review discusses the fundamentals of sustained release formulations and the many varieties available. Key words: Matrix tablets, Sustained release, Sustain release polymers, Patient convenience and compliance.

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Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac

Cited by 29 publications

References 21 publications

Physicochemical Evaluation of Diploknema butyracea Seed Extract and Formulation of Ketoconazole Ointment by Using the Fat as a Base

Physicochemical Evaluation of Diploknema butyracea Seed Extract and Formulation of Ketoconazole Ointment by Using the Fat as a Base

Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters

Design, Development and Evaluation of Matrix Tablet

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