Formulation and Evaluation of Mouth Dissolving Tablet of Meloxicam Using Natural Superdisintegrants

Pawar, Chetan V; Mutha, Swati; Bhise, Sagar V; Borawake, Payal D

doi:10.22159/ajpcr.2020.v13i2.34838

Cited by 6 publications

(5 citation statements)

References 8 publications

(9 reference statements)

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“…This study the stage for the importance of solid dispersions in overcoming challenges associated with oral drug delivery. It highlights poor solubility and permeability as key factors affecting bioavailability and introduces solid dispersions as a potential solution [2,5].…”

Section: Improving Oral Bioavailability Of Meloxicam: Development And...mentioning

confidence: 99%

Improving Oral Bioavailability of Meloxicam: Development and Characterization of Solid Dispersions

Ratan,

Malik,

Singh

et al. 2024

JBPR

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This study investigated the development of a solid dispersion to improve the solubility and dissolution of meloxicam, a poorly water-soluble drug. Meloxicam is used to treat pain and inflammation in various conditions. The challenge was to enhance the drug's oral bioavailability by overcoming its low solubility. Two approaches were explored: 1. Kneading method with Poloxamer 407: This method resulted in a formulation with significantly improved solubility compared to the pure drug. Solvent evaporation method with PVP K-30: While this method offered satisfactory solubility enhancement, it was not as effective as the kneading method with Poloxamer 407.Following the development of the optimized solid dispersion, a suspension formulation was prepared using various suspending agents. The optimized drug formula was then incorporated into the suspension mix. Characterization studies confirmed compatibility between the drug and excipients. FT-IR analysis showed no interaction between the drug and the carriers. Scanning electron microscopy (SEM) revealed a change in meloxicam particle morphology from crystalline to a more amorphous form, indicating a reduction in particle size and a potential explanation for the improved dissolution profile. The dissolution profile of the solid dispersion suspension prepared by the kneading method with Poloxamer 407 outperformed the one prepared with the solvent evaporation method and PVP K-30.This study demonstrates the effectiveness of the kneading method with Poloxamer 407 in developing a solid dispersion of meloxicam with enhanced solubility and dissolution. The optimized formulation exhibited good stability, acceptable drug content and release, and satisfactory rheological properties. This approach has the potential to improve the bioavailability of meloxicam and lead to a more effective oral dosage form. Keywords: Oral Bioavailability, Meloxicam:, Solid Dispersions , FT-IR analysis, SEM

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Section: Improving Oral Bioavailability Of Meloxicam: Development And...mentioning

confidence: 99%

Improving Oral Bioavailability of Meloxicam: Development and Characterization of Solid Dispersions

Ratan,

Malik,

Singh

et al. 2024

JBPR

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“…The Drug was identified by various physicochemical properties such as Color, Odour, Melting point, DSC analysis, and FT-IR spectroscopy [7].…”

Section: Physicochemical Characterization Of Drugmentioning

confidence: 99%

Formulation of Solid Dispersions for Enhancement of Solubility and Dissolution Rate of Simvastatin

Borawake¹,

Kauslya²,

Shinde³

2021

Int J Pharm Pharm Sci

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Objective: The objective of the present work was to formulate the solid dispersions of simvastatin for enhancement of its aqueous solubility and dissolution rate. Methods: In the present study, solid dispersions of simvastatin were prepared by Kneading and Solvent evaporation methods. The polymeric carriers like Polyethylene glycol (PEG) 6000 and Polyvinyl Pyrrolidone (PVP) K30 were used in different ratios (ratio of drug: carrier was 1:1, 1:2) to formulate solid dispersions. The prepared solid dispersions were characterized by differential scanning calorimetry (DSC), Fourier transforms infrared spectroscopy (FTIR), and evaluated for drug content, percentage yield, saturation solubility, in vitro dissolution studies. The best formula of the solid dispersion was selected according to the solubility and dissolution data. Results: The F7 formulation was found to be an optimized formulation containing PVP K30 in the ratio 1:1 prepared by solvent evaporation technique. The Drug content was found to be higher i.e. 94.89 in the F7 batch. The FT-IR spectra revealed that there was no interaction between drugs and carriers. DSC thermogram indicated entrapment of simvastatin in PVP K30 and the conversion of crystalline simvastatin into an amorphous form. The F7 formulation showed maximum drug release i.e. 98.60% in 60 min which is 2 times greater than pure drug making it an optimized formulation. Conclusion: The solubility of simvastatin was successfully enhanced through the solid dispersion technique. Solid dispersions prepared with solvent evaporation method were more soluble than solid dispersions prepared with kneading method with carrier PVP K30.

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“…Powder mixture of KRT, with one of the superdisintegrant crospovidone, crosscarmellose sodium and sodium starch glycollate were dry blended for 20min followed by addition of mannitol and aspartame. The mixtures were then mixed with magnesium stearate and talc and further blended for 10 min and resultant powder blend was directly compressed using rotary tablet machine with 9 mm flat round punches to obtain the MDT tablets containing 10mg of KRT [11][12] . It is the ratio of total mass of powder to the bulk volume of powder.…”

Section: Formulation Of Mouth Dissolving Tablets Of Ketorolac Tromethmentioning

confidence: 99%

Formulation and Evaluation of Ketorolac Tromethamine Mouth Dissolving Tablets

Bindal

Indurkhya

2021

J. Drug Delivery Ther.

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Due to more versatility and comfort, mouth dissolving tablets are the most advanced type of oral solid dosage forms. Compared to conventional tablets, it increases the effectiveness of APIs by dissolving within a minute in the oral cavity after contact with less saliva, without chewing and without the need for water for administration. Mouth Dissolving Tablets of Ketorolac tromethamine were prepared by direct compression method using various superdisintegrants like crospovidone, Croscarmellose sodium, and Sodium starch glycolate in different concentrations. Prepared tablets were evaluated for hardness, friability, weight variation, disintegration time, wetting time and in vitro drug release. Results of pre-compression and post-compression studies of all formulations were found within the standard limits. The tablets of all the batches were found to release more than 80% of drug in 5 minutes, which is the desired quality of mouth dissolving tablets that helps in faster absorption of the drug and quick onset of therapeutic effect. The the order of dissolution of various disintegrants was found to be Crospovidone˃ SSG˃ CCS. There was no significant variation in drug content of drug during stability studies for selected batch F3 in accelerated conditions over three months. It was concluded from the study that fast release of Ketorolac tromethamine from formulation F3 may reduce onset of drug action with better patient compliance. Keywords: Crospovidone, Croscarmellose sodium, Ketorolac tromethamine, Mouth dissolving tablets, Sodium starch glycolate, superdisintegrants.

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Formulation and Evaluation of Mouth Dissolving Tablet of Meloxicam Using Natural Superdisintegrants

Cited by 6 publications

References 8 publications

Improving Oral Bioavailability of Meloxicam: Development and Characterization of Solid Dispersions

Improving Oral Bioavailability of Meloxicam: Development and Characterization of Solid Dispersions

Formulation of Solid Dispersions for Enhancement of Solubility and Dissolution Rate of Simvastatin

Formulation and Evaluation of Ketorolac Tromethamine Mouth Dissolving Tablets

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