Formulation and Evaluation of Metronidazole Loaded Nanosponges for Topical Delivery

Khan, Rashid Ali; Saif, None Anum; Naureen, Humaira; Sarwar, Atif; Shahbaz, Muhammad Ali; Arif, Muhammad Nouman

doi:10.55627/pharma.001.001.0185

Pharmaceutical Communications

2022

DOI: 10.55627/pharma.001.001.0185

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Formulation and Evaluation of Metronidazole Loaded Nanosponges for Topical Delivery

Rashid Ali Khan

None Anum Saif

Humaira Naureen

et al.

Abstract: Formulations of metronidazole M1, M2, M3, M4, and M5 with the polymer ethyl cellulose and M1, M2, M3, M4 and M5* with the polymer Eudragit RS100 at varying concentrations were prepared and characterized by Zeta sizer, SEM, DSC, FTIR and XRD. The gel was evaluated for its spreadability, skin irritancy, entrapment efficiency and drug release. Size in M5* was 292.2 nm with PDI of 1.00 and in M2, 371.8 nm with PDI of 0.809 was observed. The entrapment efficiency and production yield with M5* was observed to be… Show more

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2024

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Development of Lipid-Based Vesicles of Terbinafine Gel for Skin Delivery by 32full Factorial Design

SARASWATHI,

ROSHINI,

DAMODHARAN

et al. 2024

Int J App Pharm

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Objective: Terbinafine is a poorly water-soluble and highly permeable allylamine antifungal (BCS-II) drug. In this study, we looked at the possibility of using ethosomes as vesicular lipid nanocarriers to enhance the transdermal delivery of terbinafine. Methods: Using a 32 full factorial design, the ethosomal formulation with different soya lecithin and cholesterol concentrations was improved and optimized. The influence of independent variables, namely soya lecithin and cholesterol concentration in ethosomes was determined by estimating dependent variable including the particle size, polydispersity index, zeta potential, entrapment efficiency, and in vitro drug release. To improve the residence time of ethosomes on the topical application, the ethosomes were incorporated into the carbopol gel. 1% w/v of Carbopol 934 P gel-embedded Terbinafine ethosomes were used to study medication release and skin interactions. Results: Optimized ratios of soya lecithin and cholestrol was used to prepare vesicles. Formulation had a particle size of 1207.39±2.71 nm, entrapment efficiency of 94.46±0.47%, and in vitro diffusion of 51.27±0.16%. It was found that the growth of fungus Aspergillus niger and Candida albicans were inhibited by Ethosomal Gel. However, ethosomal gel had more inhibitory activity on Apergillus niger compared to positive control. Conclusion: The current study suggests that ethosomal vesicles may improve transdermal dispersion without causing skin irritation. Terbinafine-loaded ethosomes have the potential to be one of the most important transdermal application techniques for the treatment of fungi-related disorders.

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Development of Lipid-Based Vesicles of Terbinafine Gel for Skin Delivery by 32full Factorial Design

SARASWATHI,

ROSHINI,

DAMODHARAN

et al. 2024

Int J App Pharm

View full text Add to dashboard Cite

show abstract

Preparation and Characterization of Fluconazole Topical Nanosponge Hydrogel

MD,

MEHBOOB,

DODDAYYA

2024

Int J Pharm Pharm Sci

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Objective: The study aimed to develop a polymeric nanosponge-based hydrogel system for enhanced topical application of fluconazole, an antifungal drug. Methods: Nanosponges were formulated using the emulsion solvent diffusion method using various polymers like hydroxypropyl methylcellulose, ethylcellulose and Eudragit RS 100. Polyvinyl alcohol and ethanol were used to prepare the aqueous and dispersed phases. Nanosponges were dispersed in an appropriate amount of gelling agent Carbopol 940 to get nanosponge gel. Drug–polymer interaction has been carried out by FTIR spectroscopy. The prepared nanosponges were evaluated for various tests like production yield, drug entrapment efficiency, compatibility and SEM studies. The nanosponge hydrogel was tested for pH, drug content, spreadability, in vitro diffusion and kinetic studies. Results: The drug entrapment efficiency of fluconazole nanosponges was found in the range of 52.3±0.84% to 80.8±0.36% for all formulations, respectively. The spreadability of prepared nanosponges gel formulation was in the range between 5.20±0.19 to 7.187±0.85. Particle size analysis showed that the average particle size of fluconazole nanosponges formulated using ethyl cellulose (F5) was found to be 334 nm. The zeta potential was found to be-10.4 mV, indicating the formulated fluconazole nanosponges (F5) had moderate stability. FTIR and DSC studies of pure drug and nanosponges suggested that the formulations were stable and there was no chemical interaction with polymer and other excipients. The optimised fluconazole topical nanosponge hydrogel (FG5) released 90.90% drug in 8 h. Conclusion: Fluconazole topical nanosponge hydrogel could be successfully prepared by emulsion solvent diffusion method. Fluconazole topical nanosponge hydrogel showed promising results under in vitro condition and thus, there exists a scope for evaluation of the developed nanosponge hydrogel for further pharmacokinetic studies, using appropriate test models.

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Formulation and Evaluation of Metronidazole Loaded Nanosponges for Topical Delivery

Cited by 2 publications

References 0 publications

Development of Lipid-Based Vesicles of Terbinafine Gel for Skin Delivery by 32full Factorial Design

Development of Lipid-Based Vesicles of Terbinafine Gel for Skin Delivery by 32full Factorial Design

Preparation and Characterization of Fluconazole Topical Nanosponge Hydrogel

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