Formulation and Evaluation of Matrix Transdermal Patches of Glibenclamide

Abstract

The present study deals with the formulation and evaluation of transdermal patches of Glibenclamide towards enhance its permeation through the skin and maintain the plasma level concentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and iso-propylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Among the formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observed for the formulations F12 and F4 i.e. 80.012 ± 2.012 % and 98.365±3.012% respectively. The mechanism of drug release was found to be Non-Fickian diffusion controlled. FT-IR studies revealed the integrity of the drug in the formulations.
 Keywords: Transdermal Patches, Glibenclamide, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies.

Formulation and evaluation of Ketorolac tromethamine for transdermal drug delivery system

“…The transdermal patch was cut into 2 cm squares to measure weight variation, and three pieces were weighed to calculate the average weight [16][17][18][19][20] .…”

“…A vernier caliper was used to measure the thickness of the three patches. Thickness was measured at three different points on the patch and the average value was recorded [16][17][18][19][20] .…”

“…A strip (2 cm x 2 cm) of a specific area was cut evenly and folded repeatedly until it broke at the same place. The number of times the film was not broken even when the film was folded at the same point was taken as the folding strength [16][17][18][19][20] .…”

“…A 2 cm square film was placed in 0.5 ml of double distilled water in a glass tube for about 1 hour and the pH of the film was calculated using a pH meter [16][17][18][19][20] .…”

“…Place the 2 cm square film into a mixture of 20 mL of methanol and 80 mL of phosphate buffer (pH 7.4) in a 100 mL volumetric flask and stir using a magnetic stirrer for 24 hours. Drug solutions were scanned by UV spectroscopy and drug content was calculated [16][17][18][19][20] .…”