Formulation and Evaluation of Madhuca Longifolia Extract Syrup for Lithiasis

Abstract

M. longifolia's natural habitat spans from the southernmost tip of the Konkan peninsula down to the westernmost tip of the Western Ghats. Previous studies suggests that syrup of Madhuca longifolia (mahua) leaves & flower extract has not been formulated yet. Lithiasis is the presence of calculi within the urinary tract. So, present study is focused on the formulation and estimation of Madhuca longifolia syrup for urolithiasis activity. The fresh leaves and flower of Madhuca longifolia were collected from the lucknow region in Uttar Pradesh. It was washed, dried under shade, and sieved for making dust-free and kept at room temperature or shade. Chemicals i.e., propylene glycol, glycerin, sucrose, sorbitol, sodium saccharin, methylparaben, and propylparaben were purchased from the local chemical supplier. The leaves and powder of Madhuca longifolia were weighed and extracted through Soxhlet process using methanol and water, separately. The syrup was formulated by adding mahua extract and different excipients. The parameters including organoleptic features, flavonoid estimation, pH determination, density, viscosity, solubility and stability. In results, both the formulation was observed as optimized in terms of their organoleptic features- greenish colour, pH (6.0), characteristic odour with bitter taste. Appearances were heterogenous. The % yield was 9.8% and 8.2% in methanolic flower extract and aqueous flower extract, respectively. It concludes that both formulation of mahua syrup consisting leaves and flowers have shown a remarkable organoleptic characteristic as well as density, solubility and stability. It also demonstrated the presence flavonoids that might be important constituent for the urolithiasis potential and other pharmacological effects of mahua. It may also be confirmed that its syrup production at bulk level would be reasonable in terms of cost. It will improve the use of herbal syrup of Madhuca longifolia with reduced side effects.