Formulation and Evaluation of Hydrogels Based on Sodium Alginate and Cellulose Derivatives with Quercetin for Topical Application

Szulc-Musioł, Beata; Siemiradzka, Wioletta; Dolińska, Barbara

doi:10.3390/app13137826

Cited by 9 publications

(4 citation statements)

References 78 publications

(82 reference statements)

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“…As expected, during rub-in, the formulation that was scored as the most spreadable was formulation A12, which showed the lowest viscosity. A close relationship between formulation viscosity and spreadability during application onto the skin surface has been reported in previous studies [86,87]. However, an increase of oil phase ratio from 12 to 14% w/w reduced the perceived ease of spreading but a further increase to 16% w/w did not alter this perception.…”

Section: Resultssupporting

confidence: 84%

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Santonocito,

Puglia,

Montenegro

2024

Preprint

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To improve efficacy and safety of sunscreen emulsions, UV‐filter skin permeation could be kept as low as possible by reducing UV‐filter content or changing emulsion composition. In this work, different lipid phase ratio (12, 14 and 16% w/w) were assessed for their ability to affect the technological and sensory properties of O/W emulsions in which bemotrizinol (BMTZ), a broad spectrum sunscreen agent, was incorporated free or loaded into nanostructured lipid nanocarriers (NLC) to reduce its release from the vehicle and, hence, its skin permeation. The following technological properties were evaluated in vitro by suitable methodologies: spreadability, viscosity, pH, occlusion factor, BMTZ release, sun protection factor (SPF). Sensory attributes were assessed by trained panelists in three different phases: before/during pick‐up, rub‐in, after application. Raising the lipid phase ratio led to an increase of viscosity and to a corresponding drop of spreadability while the incorporation of BMTZ‐loaded NLC determined a decrease of occlusion factor and an increase of SPF. No BMTZ release was observed from all emulsions. Sensory attributes were mainly affected by lipid phase ratio. These results suggest that lipid phase ratio and BMTZ incorporation into NLC could contribute to determine technological and sensory properties of O/W emulsions.

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Section: Resultssupporting

confidence: 84%

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Santonocito,

Puglia,

Montenegro

2024

Preprint

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“…The organoleptic characteristics of the drug, including its appearance, taste, and odor, were evaluated and found to comply with pharmacopeial standards, ensuring its identity and quality [37]. The determination of Qu's melting temperature at 316 • C through multiple measurements corroborated its purity and stability, further reinforcing its suitability for pharmaceutical use [38].…”

Section: Discussionmentioning

confidence: 88%

Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential

Sharma,

Basist,

Alhalmi

et al. 2023

Micromachines

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The study delves into the multifaceted potential of quercetin (Qu), a phytoconstituent found in various fruits, vegetables, and medicinal plants, in combination with silver nanoparticles (AgNPs). The research explores the synthesis and characterization of AgNPs loaded with Qu and investigates their pharmaceutical applications, particularly focusing on antibacterial properties. The study meticulously evaluates Qu’s identity, and physicochemical properties, reaffirming its suitability for pharmaceutical use. The development of Qu-loaded AgNPs demonstrates their high drug entrapment efficiency, ideal particle characteristics, and controlled drug release kinetics, suggesting enhanced therapeutic efficacy and reduced side effects. Furthermore, the research examines the antibacterial activity of Qu in different solvents, revealing distinct outcomes. Qu, both in methanol and water formulations, exhibits antibacterial activity against Escherichia coli, with the methanol formulation displaying a slightly stronger efficacy. In conclusion, this study successfully synthesizes AgNPs loaded with Qu and highlights their potential as a potent antibacterial formulation. The findings underscore the influence of solvent choice on Qu’s antibacterial properties and pave the way for further research and development in drug delivery systems and antimicrobial agents. This innovative approach holds promise for addressing microbial resistance and advancing pharmaceutical formulations for improved therapeutic outcomes.

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“…At high rotation speeds (50-100 rpm), this decrease was less, and the measurements were repeated from 100 rpm to 2.5 rpm (down viscosity ramp), it was stated that the same results were reached and the viscosity did not change depending on the time [40]. Based on the increased shear stress, polymer particles moved in the direction of flow and reduced the viscosity of the system, that was, the pseudoplastic flow type was seen [41]. As a result, our findings were compatible with the literature.…”

Section: Viscosity Flow Characteristics and Spreadabilitymentioning

confidence: 96%

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Davut ARPA,

DOĞAN,

GÜNDÜZ

et al. 2024

jrp

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Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid (AZE), and erythromycin are used alone or in combination. AZE cream (20%) has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl β-cyclodextrin (HβC). In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose (HPMC). The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-HβC hydrogel formulations had a similar cumulative release percent as HβC-free hydrogels but showed a higher cumulative release percent than the commercial cream (Azelderm, Orva, Türkiye). It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference (f1) and similarity (f2) factors.

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Formulation and Evaluation of Hydrogels Based on Sodium Alginate and Cellulose Derivatives with Quercetin for Topical Application

Cited by 9 publications

References 78 publications

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

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