Formulation and Evaluation of Floating Tablets of Cefpodoxime Proxetil

Abstract

In present investigation, an attempt was made to develop gastro retentive tablets of cefpodoxime proxetil (CP) using locust bean gum as release retarded material. CP is an orally administered, extended spectrum, semi-synthetic antibiotic of cephalosporin class. CP has a short elimination half-life and also possesses high solubility, chemical, enzymatic stability and absorption profiles in acidic pH which makes CP suitable candidate for formulating it as gastro retentive dosage form for improved bioavailability. Sodium bicarbonate and citric acid were used as effervescent agents to get desired floating properties. The tablets prepared were evaluated and found to have acceptable physicochemical properties. The in vitro release data of optimized formulation was treated with mathematical equations and was concluded that drug release followed zero order kinetics with anomalous transport mechanism. Based on the results it can be concluded that floating tablets of cefpodoxime proxetil containing locust bean gum provides a better option for controlled release action and improved bioavailability.

Formulation development and in-vitro evaluation of floating sintered matrix tablets of Cefpodoxime Proxetil using carnauba wax

“…Evaluation tests such as weight variation, thickness, hardness, friability, assay/drug content, and buoyancy/floating tests were performed. By application of floating CP tablet exposed to 40 ºC in a hot air oven for evaporation of menthol, in-vitro dissolution was conducted for the prepared tablets [1,13,14].…”

“…These systems can be utilized to achieve either local or systemic effects. Osmotic pressure-activated drug delivery systems, which represent a novel generation of pharmaceuticals, have obtained regulatory approval for commercialization owing to their clinical benefits in comparison to sustainedrelease and quick-release products [1,2].…”

“…The formulation of a gastroretentive dosage form is feasible due to the compound's brief elimination half-life and efficient absorption in an acidic pH environment [8]. Latha Kukati et al formulated and evaluated sintered floating tablets of cefpodoxime proxetil for gastro-retentive application using a chemical sintering technique with acetone [1]. 10 Pre-formulation studies were performed to test the physical and chemical properties of a drug alone and with a combination of excipients.…”

Development and Characterization of Atorvastatin Calcium Sustained Release Tablet Using Carbomer-974 and Hypromellose-15000 cps

“…Previously we reported the use of different polymers like methyl cellulose, Kollidon SR, HPMC for sustained release dosage form design [4,5] while other researchers mentioned the use of PVP-K30 and Locust bean gum as a rate retardant in floating drug delivery [6]. The present investigation was focused to develop Atorvastatin Calcium sustained release tablet to evaluate the effect of polymer Carbomer-974 and Hypromellose-15000 cps on drug release behavior from the prepared formulations.…”

Applicability of Gum Karaya in the Preparation and <I>in Vitro</I> Evaluation of Losartan Potassium as Chronotherapeutic Drug Delivery System

“…Gum karaya (GK), also called as Sterculia gum, is the dried exudation of the Sterculia urens tree and other species of Sterculia, which belong to the family Sterculiaceae [5,6]. GK is a negative colloid and a high-molecular-mass complex acidic polysaccharide.…”