Formulation and Evaluation of Fenofibrate-loaded Nanoparticles by Precipitation Method

Shelake, Sardar S.; Patil, S. V.; Patil, S. S.

doi:10.4172/pharmaceutical-sciences.1000374

Cited by 18 publications

(7 citation statements)

References 8 publications

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“…5 which demonstrates the high-intensity diffraction peaks for pure allopurinol drug (2θ = 14.61°, 17.35°, 25.80°, 27.68°), depicting its crystalline nature. However, the intensity of diffraction peaks of pure AL was reduced in A-CNPs formulation, confirming its successful encapsulation in the A-CNPs and its transformation from less soluble crystalline form to more soluble amorphous form [23].…”

Section: X-ray Diffractionmentioning

confidence: 86%

Formulation and Evaluation of Allopurinol Loaded Chitosan Nanoparticles

2019

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Objective: The objective of the present investigation was to fabricate and characterize allopurinol loaded chitosan nanoparticles (A-CNPs) for sustained release of drug. Methods: The allopurinol loaded chitosan nanoparticles were successfully prepared by employing the ionotropic gelation method. Further, particle size (PS), polydispersity index (PDI), zeta potential (ZP), Differential Scanning Calorimetry (DSC), entrapment efficiency (EE), Transmission Electron Microscopy (TEM), in vitro drug release, X-Ray Diffraction (XRD) and Fourier transform infrared (FTIR) were used for evaluating formulated A-CNPs Results: A-CNPs was successfully prepared and the particle size, polydispersity index, ZP and entrapment efficiency were found to be 375.3±10.1 nm, 0.362±0.01 and 32.5±2.7 mV and 52.56±0.10% respectively. In vitro release profile of A-CNPs showed sustained release and Higuchi model was found to be best fit for drug release kinetics. FTIR study depicted no chemical interaction between pure drug allopurinol (AL) and other excipients. Conclusion: The sustained release formulation of allopurinol was successfully prepared using HMW chitosan and evaluated for different parameters.

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Section: X-ray Diffractionmentioning

confidence: 86%

Formulation and Evaluation of Allopurinol Loaded Chitosan Nanoparticles

2019

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“…Polymeric nanocarriers are useful for active or passive breast cancer targeting. [5] 2018 Cellulose acetate Ultrabright fluorescent nanoparticles For imaging tumors through systemic and topical applications 2 Melnychuk et al [6] 2018 Dyes in a polymer matrix Ultrabright fluorescent nanoparticles Amplified detection of nucleic acids 3 Goetz et al [7] 2016 Lanthanide Ultrabright nanoparticles Photosensitizing behaviour was used of targeting delivery 4 Shulov et al [8] 2015 Rhodamine Ultrabright nanoparticles For bioimaging and light-harvesting delivery 5 Sun et al [9] 2013 Polyethyleneimine Ultrabright/Multicolorful Fluorescence Combined imaging and therapy applied 6 Bok et al [10] 2012 Organosilicate Ultrabright suprananoparticles Fluorescence imaging for the theranostic application [11] 2019 Doxorubicin Polymeric nanoparticle Assessed of anticancer efficiency 2 Shelake et al [12] 2018 Fenofibrate Polymeric nanoparticle Bioavailability enhancement of the poorly soluble drugs 3…”

Section: Type Of Nanocarriers In the Management Of Diseases And Disor...mentioning

confidence: 99%

“…Tumor targeting for the bioavailability enhancement 4 Bohrey et al [14] 2016 Diazepam Polymeric nanoparticle biocompatibility and controlled drug release 5 Solar et al [15] 2015 2 displays polymeric nanocarrier research and reviews. [11][12][13][14][15] Ultrasound mediated nanocarriers With ultrasound, nanoparticles transport liquid emulsions and solid genes in vitro and in vivo. Small packaging lets nanoparticles enter tumours.…”

Section: Polymeric Nanoparticlementioning

confidence: 99%

The emergence of nanocarriers in the management of diseases and disorders

Khulbe

Singh

Aman

et al. 2023

Community Acquir Infect

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Drugs can be delivered using oral nanocarriers in controlled, site-specific releases. Target receptors are physically, chemically, and biologically conjugated while administering a specific medicine. Since micro carriers have a 200 nm width, nanomedicine typically refers to objects with that size. Drugs can be delivered by nanocarriers to parts of the body that are inaccessible. Nanocarriers cannot deliver large pharmaceutical dosages due to their small size. Emulsion-based nanocarriers often have poor drug loading and encapsulation, which restricts their potential for therapeutic use. Various therapeutic nanocarriers exist. Ultrabright nanocarriers, polymeric nanocarriers, smart nanocarriers, nanocomposites, protein nanocarriers, nucleic acid-based nanocarriers, carbon nanotubes, and nanobubbles are examples of novel nanocarriers. All of them have successfully treated cancer. This review looks at targeted drug delivery methods and nanocarriers.

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“…51 Example: JNJ-25894934 New molecule entity, 52 Pioglitazone. 53 ultrafine Rifampicin particles, 54 Fenofibrate-loaded nanoparticles by precipitation method, 55 , Curcumin using HPMC K 15M by Solvent Change Precipitation Method 56 etc.…”

Section: Precipitationmentioning

confidence: 99%

Strategies for improving hydrophobic drugs solubility and bioavailability

Gupta,

Dakhole,

Jinnawar

et al. 2023

IJPCA

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Nowadays various drugs synthesized by various computational drug designs as well as various drugs have complex structure. Due to their complex structure, higher molecular weight which will increases solubility issues. Solubility is the most important and challenging task for researchers. Bioavailability and absorption of a drug depends on solubility of drug and thus we achieve pharmacological response. But poor aqueous solubility is a rate limiting step in bioavailability which made drug development more difficult. Drugs having low bioavailability require to be administered at a higher dose to achieve desired drug concentration in the systemic circulation and reach the target site. Thus, instead of getting desired effects drug produces side effects in the gastrointestinal tract. Hence, with the advancement of chemical science, the need of development of pharmaceutical technologies is also increasing. New techniques have been developed with a focus on enhancement of the solubility and oral bioavailability of poorly water-soluble drugs. The present review focuses on new technologies which are being used to resolve solubility issue of poorly soluble drugs which is the rate limiting step in bioavailability.

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Formulation and Evaluation of Fenofibrate-loaded Nanoparticles by Precipitation Method

Cited by 18 publications

References 8 publications

Formulation and Evaluation of Allopurinol Loaded Chitosan Nanoparticles

Formulation and Evaluation of Allopurinol Loaded Chitosan Nanoparticles

The emergence of nanocarriers in the management of diseases and disorders

Strategies for improving hydrophobic drugs solubility and bioavailability

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