Formulation and Evaluation of Fast Dissolving Tablets of Ofloxacin by Direct Compression Method

Aripiprazole is an antipsychotic medication, works by changing the actions of chemicals in the brain. It is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression). In order to formulate a newer aripiprazole immediate release of strength 30mg we performed the drug characterization study for the active pharmaceutical ingredient. Morphological characteristics, melting point, angle of repose, bulk density, tapped density, carr's index, hausner ratio, sieve analysis, water content and moisture pick up were determined. The results obtained were satisfactory and within the specified limits. The drug characterization study was found to be useful for formulation and development of aripiprazole immediate release tablet.

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“…In order to perform the drug characterization study for the selected anti-psychotic drug the following studies were carried out 17,18 :…”

Section: Drug Characterization Studymentioning

confidence: 99%

Drug Characterization Study of Aripiprazole for Formulation and Development of Newer Antipsychotic Formulation

Kumar¹,

Basak²,

Babu³

2017

Int. Res. J. Pharm.

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“…Various antibacterial drugs are used to treat bacterial infections like-ciprofloxacin, nalidixic acid, norfloxacin acid, rosoxacin, etc., but these drugs are effective or work on some particular bacteria [2,3]. However, ofloxacin is a drug of 1 st -generation fluoroquinolones which is works on both grams (-) & gram (+) bacteria [4]. The bioavailability of the ofloxacin is highly dependent on the specific physiology in the digestive system and is ideally consumed in the higher intestinal region.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Oral Mucoadhesive Microspheres of Ofloxacin for Peptic Ulcer Use

et al. 2023

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A peptic ulcer is a disease that affects the stomach lining caused by Helicobacter pylori. The present research aimed to formulate and evaluate the mucoadhesive microsphere of ofloxacin for the effective and safe treatment of peptic ulcers. The mucoadhesive microspheres were developed using natural polymers like Guar gum, Sodium alginate, and Chitosan using the emulsification cross-linking method. A total of 8 batch formulations were prepared using 23 full factorial designs. The prepared microspheres were evaluated various parameters such as % yield, entrapment efficiency, drug release study, in vitro wash-off test, optimization was done by the design of expert which was further subjected to statistical analysis that was kinetic release mechanism, compatibility studies were performed such as FTIR and DSC. Using factorial design 23 for the maximum possible formulation, the optimized formulation was found to be F5 in terms of better release for a longer time and with better mucoadhesive properties on the use of guar gum, sodium alginate, and chitosan in ratio 1:1:2. Second-order polynomial equations were derived for absorbing responses after the application of ANOVA, after omitting the non-significant (p ≥ 0.05) coefficients. %CDR 56.10 % for an extended period of 8 h, % EE exhibited 86.25±1.16. The sustained release activity of F5 might be due to the adhesion of the polymer to the gastric mucosa for more extended periods of 71 % to 8 h. it is also favoured by the suitable particle size of the optimized formulation. The result indicated that the prepared mucoadhesive microspheres can release the ofloxacin in sustained manner and helps in the management of peptic ulcer. HIGHLIGHTS Ofloxacin loaded mucoadhesive microsphere was prepared for treatment of peptic ulcer The mucoadhesive microspheres were developed using natural polymers A total of 8 batch formulations were prepared using 23 full factorial designs Drug release from the optimized microsphere was 71 % to 8 h The developed microsphere can effectively deliver the drug in stomach part GRAPHICAL ABSTRACT

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Formulation and Evaluation of Famotidine Fast Dissolving Tablets Using Synthetic Superdisintegrants

Rajeswari

Kumari

2019

Int J Pharm Pharm Sci

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Objective: The main aim of the present research work was to formulate fast dissolving tablets of famotidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern. Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants (2, 4 and 6 %w/w), mannitol 20 % and microcrystalline cellulose (44, 46 and 48 % w/w) as a directly compressible vehicle. All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies. Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits. Based on in vitro drug release studies (>90 % within 30 min), the optimised formulations were optimised tested for the short term stability (at 40 ˚C/75% RH for 3 mo) and drug excipient interaction (fourier transform infrared spectroscopy). Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidine and 44 % w/w of microcrystalline cellulose as emerged as the overall best formulation (>90 % within 30 min) compared to marketed product (>70 % within 30 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release (p<0.05).

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Formulation and Evaluation of Fast Dissolving Tablets of Ofloxacin by Direct Compression Method

Cited by 3 publications

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Drug Characterization Study of Aripiprazole for Formulation and Development of Newer Antipsychotic Formulation

Drug Characterization Study of Aripiprazole for Formulation and Development of Newer Antipsychotic Formulation

Formulation and Evaluation of Oral Mucoadhesive Microspheres of Ofloxacin for Peptic Ulcer Use

Formulation and Evaluation of Famotidine Fast Dissolving Tablets Using Synthetic Superdisintegrants

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