Formulation and Evaluation of Emulgel loaded with leaf extract of Artemisia princeps for its Anti-Inflammatory potential

Abstract

Indian Systems of Medicine have their roots in ayurveda. The potential of naturally occurring bioactive components is of tremendous interest to researchers. Different plant extracts have remedial properties.North India, Japan, China, Korea and Nepal are among the countries where Artemisia princeps can be found.Apigenin, diosmetin, eriiodicytol, eupafolin, kaempferol, vitex, jaceosidine, and quercetins have all been discovered in plant extracts of Artemisia princeps. It is used to treat fever, apoptosis, pain, ulcers, inflammation, and other conditions as well as Diarrhoea and Asthma.Recent in-vivo and in-vitro research have shown that it has anti-inflammatory and analgesic properties. The objectives of proposed research work are to formulate, evaluate and optimize the Emulgel loaded with optimised extract of Artemisia princepsand assess its In-Vitro Anti-Inflammatory Activity. Collected leaves of Artemisia princeps was extracted using hydro-alcoholic solvent. On the basis of their Phytochemical evaluation, the extract was optimized. Additional 6 batches of Emulgel were created utilizing a chosen extract. The prepared Emulgel was assessed for pH, spreadability, viscosity, consistency, appearance, colour, infrared spectral assignment, and appearance. Using the HRBC Membrane stabilisation assay, extract and formulation were tested for in vitro anti-inflammatory efficacy. The suggested study project's findings support the potential for future topical application of the newly developed Emulgel, which contains Artemisia princeps leaf extract, to reduce inflammation.