Formulation and evaluation of diclofenac sodium buccoadhesive discs

El-Samaligy, Mohamed S.; Yahia, Shaimaa; Basalious, Emad B.

doi:10.1016/j.ijpharm.2004.07.033

Cited by 81 publications

(44 citation statements)

References 23 publications

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“…Buccal discs are designed to minimize the discomfort caused due to bulky tablet buccal dosage forms. Several buccal discs have been extensively reported for successful delivery of therapeutic drug molecules (Han et al, 1999;El-Samaligy et al, 2004;Yehia et al, 2008;Jaipal et al, 2013;Sander et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Jaipal

Pandey

et al. 2014

Drug Delivery

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Section: Introductionmentioning

confidence: 99%

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Jaipal

Pandey

et al. 2014

Drug Delivery

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“…Each mucoadhesive film was adhered by cyanoacrylate glue to the beaker side wall (25 ml beaker) (19). Each covered vessel containing 10 ml phosphate buffer pH 6.8 was placed in a shaking incubator rotating at a rate of approximately 150 strokes per minute.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Design and In Vitro/In Vivo Evaluation of Ultra-Thin Mucoadhesive Buccal Film Containing Fluticasone Propionate

et al. 2016

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ABSTRACT. Fluticasone propionate is a synthetic corticosteroid drug distinguished by its potent antiinflammatory action with low systemic side effects in comparison to other corticosteroids making it a potential drug for local buccal delivery. The aim of the present study was to design mucoadhesive buccal film containing fluticasone that is aesthetically acceptable and could maintain local drug release for a sustained period to manage the sign and symptoms of severe erosive mouth lesions. Solvent casting technique was used in film preparation. Different polymeric blends were used either alone or in combination with mucoadhesive polymers, sodium carboxymethyl cellulose (SCMC), or Carbopol 971P at different concentrations. The physicochemical properties, in vitro mucoadhesion time as well as the drug release properties for all prepared formulations were determined. Selected formulations with adequate properties were further examined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) and subjected to in vivo evaluation. Films containing hydroxypropyl methylcellulose (HPMC)/ ethyl cellulose (EC) showed acceptable physicochemical properties, homogenous drug distribution, convenient mucoadhesion time, moderate swelling as well as sustained drug release up to 12 h. The biological performance of these formulations was assessed on healthy human volunteers and compared with a prepared mouthwash which showed enhanced pharmacokinetic parameters for the selected films in comparison to the mouthwash. The results revealed that the optimized formulation containing HPMC/EC and 10% SCMC could successfully achieve sustained drug release for 10 h which is considered promising for local treatment of severe mouth lesions.

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“…The release of fluconazole from the prepared bioadhesive discs into phosphate buffer pH 6.8 at 37±0.5°C was performed where each bioadhesive disc was adhered to the side wall of a vessel (100 mL beaker) using cyanoacrylate (8). Adequate sink conditions were provided by placing 50 mL of phosphate buffer pH 6.8 in each vessel.…”

Section: In Vitro Release Of Fluconazole From Different Buccal Discsmentioning

confidence: 99%

“…The in vitro adhesion time of fluconazole discs was evaluated by assessing the time for these discs to detach from a chicken pouch membrane in a well-stirred beaker (8,15). The chicken pouch membranes were fixed on the side of the beaker with cyanoacrylate glue.…”

Section: Determination Of In Vitro Adhesion Time Of Fluconazole Buccamentioning

confidence: 99%

Design and In Vitro/In Vivo Evaluation of Novel Mucoadhesive Buccal Discs of an Antifungal Drug: Relationship Between Swelling, Erosion, and Drug Release

2008

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Abstract. Two groups of fluconazole mucoadhesive buccal discs were prepared: (a) Fluconazole buccal discs prepared by direct compression containing bioadhesive polymers, namely, Carbopol 974p (Cp), sodium carboxymethyl cellulose (SCMC), or sodium alginate (SALG) in combination with hydroxypropyl methylcellulose (HPMC) or hydroxyethyl cellulose (HEC). (b) Fluconazole buccal discs prepared by freeze drying containing different polymer combinations (SCMC/HPMC, Cp/HPMC, SALG/HPMC, and chitosan/SALG). The prepared discs were evaluated by investigating their release pattern, swelling capacity, mucoadhesion properties, and in vitro adhesion time. In vivo evaluation of the buccal disc and in vivo residence times were also performed. Fluconazole salivary concentration after application of fluconazole buccal systems to four healthy volunteers was determined using microbiological assay and high-performance liquid chromatography. SCMC/HPMC buccal disc prepared by direct compression could be considered comparatively superior mucoadhesive disc regarding its in vitro adhesion time, in vivo residence time, and in vitro/in vivo release rates of the drug. Determination of the amount of drug released in saliva after application of the selected fluconazole disc confirmed the ability of the disc to deliver the drug over a period of approximately 5 h and to reduce side effects and possibility of drug interaction encountered during systemic therapy of fluconazole, which would be beneficial in the case of oral candidiasis.

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Formulation and evaluation of diclofenac sodium buccoadhesive discs

Cited by 81 publications

References 23 publications

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Design and In Vitro/In Vivo Evaluation of Ultra-Thin Mucoadhesive Buccal Film Containing Fluticasone Propionate

Design and In Vitro/In Vivo Evaluation of Novel Mucoadhesive Buccal Discs of an Antifungal Drug: Relationship Between Swelling, Erosion, and Drug Release

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