Formulation and evaluation of curcumin microsponges for oral and topical drug delivery

Bhatia, Meenakshi; Saini, Megha

doi:10.1007/s40204-018-0099-9

Cited by 38 publications

(26 citation statements)

References 21 publications

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“…Empty aluminum pan was used as a reference. The heat flow as a function of temperature was measured for the samples 8 .…”

Section: Materials and Methods: Preformulation Studies: Identificatiomentioning

confidence: 99%

Untitled

2019

IJPSR

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The objective of the present study was to formulate and evaluate a gastro-retentive stomach specific novel floating in-situ gelling system of curcumin for potentially treating gastric ulcer, associated with Helicobacter pylori. The in-situ gel of curcumin was prepared by dissolving different concentrations of gelling polymer like sodium alginate in distilled water at 60 ºC. After cooling to 40 ºC, required quantities of sodium citrate and calcium carbonate were dispersed in it with continuous stirring followed by the addition of curcumin and sorbitol. Identification of drug was confirmed by DSC (melting point study), FTIR (functional groups study), and UV spectrophotometric analysis. Compatibility between drug and polymer were confirmed by DSC and FTIR studies. The micromeritic properties of curcumin were done, and all formulations showed pH in the range of 6.6 to 7.4, floating lag time was less than 1 min, duration of floating was more than 24 h for all the prepared formulations. Gelling capacity, gel strength, viscosity, and water uptake by the gel increased with the increase in sodium alginate concentration; the drug content was found to be in the range of 92.5 to 99.1%. Drug release was found to decrease with the increase in polymer concentration of gel. The release kinetics of all the formulations followed zero order mechanism. INTRODUCTION: Floating oral in-situ gel forming system are widely explored for gastro retention purposes and have a bulk density lower than gastric fluids and thus remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period. While the system is floating on gastric contents, the drug is released slowly at a desired rate from the system.

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“…Empty aluminum pan was used as a reference. The heat flow as a function of temperature was measured for the samples 8 .…”

Section: Materials and Methods: Preformulation Studies: Identificatiomentioning

confidence: 99%

Untitled

2019

IJPSR

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“…The particle size distribution for TNF-containing microsponges of formulations F1-F5 is shown in Figure 7. The typical particle size of microsponges was found in the range of 4.52 -8.98 µm [14].…”

Section: Particle Size Analysismentioning

confidence: 99%

Formulation Development and In Vitro Release Studies of Tenofovir-containing Microsponges

Eslavath¹,

Bakshi²,

Jadi

2019

INNOSC Theranostics and Pharmacological Sciences

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Background. Microsponges are intended to carry drugs with minimum dose, while delivering beneficial effects such as better drug stability and reduced adverse effects in recipients. The present investigation was aimed to develop and characterize microsponges containing tenofovir (TNF). Methods. Quasi-emulsion diffusion technique was used to prepare TNF-containing microsponges. Eudragit L-100 was used as a polymer, whereas glycerol and dibutylphthalates were used as plasticizers. Drug and polymer were experimented in five formulations (F1-F5) of different ratios such as 1:1, 1:2, 1:3, 1:4, and 1:5. They were characterized for various physical parameters such as size, crystallinity, and interactions. Results. Fourier-transform infrared spectroscopic results showed that there was no incompatibility between the drug and excipients. Drug entrapment efficacy was found between 47% and 67%, and the particle size ranges were between 4.52 μm and 8.98 μm. Cumulative drug diffusion of formulation F2 (drug:polymer ratio = 1:2) was found to be 84.15% in 180 min for an X-ray diffraction studies of pure drug and microsponges formulation clearly indicated the reduction in the crystallinity of the drug which could be the reason for the improved solubility of the drug. Scanning electron microscopy analysis results indicated that the formulations have excellent structure and almost all formulations exhibited in spherical shape. Conclusion. Based on all the evaluation parameters, formulation F2 was concluded as the best formulation, and it is an alternative approach for conventional therapy with better patient compliance.

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“…The skin was formerly submerged in normal saline solution (0.948%w/v) and then ixed between the compartments of Franz diffusion cell; one ml samples were withdrawn periodically by maintaining perfect sink conditions and analyzed by UV spectrophotometer at 248 nm against PBS pH 7.4. The drug release pro ile was calculated against time (Bhatia and Saini, 2018) .…”

Section: Ex Vivo Diffusion Studymentioning

confidence: 99%

“…Stability studies are carried out as per ICH norms; optimized gel formulation was illed in aluminum tube and are exposed to 40 • C and 75% RH in a stability chamber. Microsponges gel was evaluated for modi ication in appearance, pH or in-vitro release pro ile at some intervals of 0, 01, 02, 03 Months (Bhatia and Saini, 2018) .…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and characterization of flurbiprofen loaded microsponge based gel for sustained drug delivery

Kshirasagar

Puchchakayala²,

Balamurgan

2019

ijrps

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The new investigation in this present work is to develop microsponges constructed novel drug delivery system for sustained action of Flurbiprofen. Quai-emulsion solvent diffusion method was engaged using Ethyl cellulose and Eudragit RS100 with drug: polymer ratio for development of microsponges. For optimization purposes, several factors are considered in the investigation. Several evaluation studies for the formed microsponges were carried out FT-IR, SEM, DSC, X-RD, particle size analysis, morphology, drug loading and In vitro drug release studies were carried out. Finally, it was concluded that there is no drug-polymer interaction as per DSC & FT-IR. Encapsulation efficiency, particle size and drug content showed a higher impact on alteration of drug-polymer ratio. SEM studies showed that morphological microsponges are spherical and porous in nature and with the mean particle size of 38.86 μm. The gel loaded with microsponges, were followed by In vitro and Ex vivo drug release studies by modified Franz diffusion cell. Skin delivery of optimized formulation enhanced the drug residence time and maintained therapeutic concentration for an extended period of time, which is possible to show sustained action of the drug.

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Formulation and evaluation of curcumin microsponges for oral and topical drug delivery

Cited by 38 publications

References 21 publications

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Formulation Development and In Vitro Release Studies of Tenofovir-containing Microsponges

Formulation and characterization of flurbiprofen loaded microsponge based gel for sustained drug delivery

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