Formulation and evaluation of cubosomes containing colchicine for transdermal delivery

Nasr, Mohamed; Younes, Hassan; Abdel-Rashid, Rania S.

doi:10.1007/s13346-020-00785-6

Cited by 47 publications

(33 citation statements)

References 40 publications

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“…The increased size with increasing ICA and GMO concentrations might be explained by the increased content of GMO in the developed Cubs. Our findings are in agreement with those in the reported literature [23,24]. As per the Pareto chart (see Figure 2), the GMO concentration has the greatest effect on the particle size, and this is also supported by the highest coefficient of independent variable B in Equation (2).…”

Section: Y1 (Particle Sizesupporting

confidence: 93%

“…The surface charges of the developed 17 ICA-Cubs were found to be within the range of +21.25 ± 0.345 mV to +28.25 ± 0.362 mV. Our findings on the surface charges of the formulated cubosomes are in agreement with those in the literature [24]. The PDI is used to see whether the colloidal system A contour plot ( Figure 3B) further confirmed the observations in the Pareto chart and the main plot effect on the particle size of the ICA-loaded cubosomal formulations.…”

Section: Y1 (Particle Sizesupporting

confidence: 90%

“…A Box-Behnken statistical design with three factors and three levels (Statgraphics software, version 15.2.05, Statgraphics Technologies, Inc., Warrenton, VA, USA) was used to optimize the ICA-Cubs formulations. Based on the available data in the literature, the maximum and minimum levels of the three independent variables (e.g., the active drug ICA, polymer GMO, and P407) were used for the identification of suitable combinations of the drug and polymers using the Quality by Design technique [23,24]. The software generated 17 different batches of different combinations of the drug, GMO, and P407 at their low (−1), medium (0), and high (+1) levels ( Table 1).…”

Section: Optimization Of the Ica-loaded Cubosomal Formulationsmentioning

confidence: 99%

“…The Entrapment Efficiency (EE) of the ICA within the ICA-Cubs was determined by the centrifugation method of Nasr et al [24]. Briefly, 1 mL of the prepared ICA-Cubs was added to 4 mL of deionized water and centrifuged at 15,000 rpm for 15 min until complete precipitation of the cubosomal nanoparticles was achieved.…”

Section: Estimation Of Entrapment Efficiencymentioning

confidence: 99%

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Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells

Fahmy

Alhakamy

2020

Pharmaceutics

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Clinical application of icariin (ICA) is limited, despite its activity against cancer growth, because of the low solubility of ICA in an aqueous environment. Therefore, the present study attempted to develop and optimize ICA-loaded cubosome delivery and to explore its efficacy and possible mechanism of action against ovarian cancer. The optimization of the cubosome formulation was performed using the Box‒Behnken statistical design; during the characterization, the particle sizes were in the range of 73 to 183 nm and the entrapment efficiency was 78.3% to 97.3%. Optimized ICA-loaded cubosomes (ICA-Cubs) exhibited enhanced cytotoxicity and apoptotic potential, compared with ICA-raw, against ovarian cancer cell lines (SKOV-3 and Caov 3). The optimized ICA-Cubs showed a relatively non-cytotoxic effect on normal EA.hy926 endothelial cells. Further analysis of cell cycle arrest suggested a potential role in the pre-G1 and G2/M phases for ICA-Cubs in comparison with ICA-raw. ICA-Cubs increased the generation of reactive oxygen species (ROS) and the overexpression of p53 and caspase-3 in the SKOV-3 cell line. In conclusion, the cubosomal delivery of ICA might provide a prospective approach towards the superior control of ovarian cancer cell growth. Its improved efficacy compared with that of the free drug might be due to the improved solubility and cellular permeability of ICA.

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Section: Y1 (Particle Sizesupporting

confidence: 93%

Section: Y1 (Particle Sizesupporting

confidence: 90%

Section: Optimization Of the Ica-loaded Cubosomal Formulationsmentioning

confidence: 99%

Section: Estimation Of Entrapment Efficiencymentioning

confidence: 99%

See 2 more Smart Citations

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells

Fahmy

Alhakamy

2020

Pharmaceutics

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“…The polydispersity index (PdI) values of all NE formulations were in the range of approximately 0.2-0.3. These PdI values are acceptable for lipid-based carriers drug delivery systems and indicating the homogeneity of the particle size [36]. The zeta potential of all CP-NE formulations was negative having a value forward to nearer zero than that of their respectively BL-NE formulations.…”

Section: Preparation and Characterization Of Cp Loaded Ne (Cp-ne)mentioning

confidence: 83%

Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies

et al. 2021

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Burst release of carbamide peroxide (CP) from traditional hydrogels causes severe inflammation to periodontal tissues. The present study explores the development of a novel CP nanoemulgel (CP-NG), an oil-in-water nanoemulsion-based gel in which CP was loaded with a view to controlling CP release. CP solid dispersions were prepared, using white soft paraffin or polyvinylpyrrolidone-white soft paraffin mixture as a carrier, prior to formulating nanoemulsions. It was found that carrier type and the ratio of CP to carrier affected drug crystallinity. Nanoemulsions formulated from the optimized CP solid dispersions were used to prepare CP-NG. It was found that the ratio of drug to carrier in CP solid dispersions affected the particle size and zeta potential of the nanoemulsions as well as drug release behavior and tooth bleaching efficacy of CP-NG. Drug release from CP-NG followed a first-order kinetic reaction and the release mechanism was an anomalous transport. Drug release rate decreased with an increase in solid dispersion carriers. CP-NG obtained from the solid dispersion with a 1:1 ratio of CP to the polymer mixture is suitable for sustaining drug release with high tooth bleaching efficacy and without reduction of enamel microhardness. The developed CP-NG is a promising potential tooth bleaching formulation.

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Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

Albakr,

Du,

Zhang

et al. 2024

Advanced NanoBiomed Research

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New advancements in nanocarrier technologies are revolutionizing the delivery of drugs through the skin, allowing for precise treatment with better absorption, stability, and bioavailability. This review investigates lipid and inorganic nanocarriers like liposomes, ethosomes, and inorganic nanoparticles and assesses their potential for delivering drugs through the skin. It emphasizes the mechanisms that enable controlled release and deeper skin penetration, which are crucial for ensuring effectiveness in clinical applications. The review synthesizes existing research, acknowledging that only few nanocarriers are successfully deployed in clinical settings. By offering a comprehensive overview, it sheds light on the progress and future obstacles to using nanocarriers for drug delivery through the skin.

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Formulation and evaluation of cubosomes containing colchicine for transdermal delivery

Cited by 47 publications

References 40 publications

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells

Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies

Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

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