2020
DOI: 10.1007/s13346-020-00785-6
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Formulation and evaluation of cubosomes containing colchicine for transdermal delivery

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Cited by 47 publications
(33 citation statements)
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“…The increased size with increasing ICA and GMO concentrations might be explained by the increased content of GMO in the developed Cubs. Our findings are in agreement with those in the reported literature [23,24]. As per the Pareto chart (see Figure 2), the GMO concentration has the greatest effect on the particle size, and this is also supported by the highest coefficient of independent variable B in Equation (2).…”
Section: Y1 (Particle Sizesupporting
confidence: 93%
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“…The increased size with increasing ICA and GMO concentrations might be explained by the increased content of GMO in the developed Cubs. Our findings are in agreement with those in the reported literature [23,24]. As per the Pareto chart (see Figure 2), the GMO concentration has the greatest effect on the particle size, and this is also supported by the highest coefficient of independent variable B in Equation (2).…”
Section: Y1 (Particle Sizesupporting
confidence: 93%
“…The surface charges of the developed 17 ICA-Cubs were found to be within the range of +21.25 ± 0.345 mV to +28.25 ± 0.362 mV. Our findings on the surface charges of the formulated cubosomes are in agreement with those in the literature [24]. The PDI is used to see whether the colloidal system A contour plot ( Figure 3B) further confirmed the observations in the Pareto chart and the main plot effect on the particle size of the ICA-loaded cubosomal formulations.…”
Section: Y1 (Particle Sizesupporting
confidence: 90%
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“…The polydispersity index (PdI) values of all NE formulations were in the range of approximately 0.2-0.3. These PdI values are acceptable for lipid-based carriers drug delivery systems and indicating the homogeneity of the particle size [36]. The zeta potential of all CP-NE formulations was negative having a value forward to nearer zero than that of their respectively BL-NE formulations.…”
Section: Preparation and Characterization Of Cp Loaded Ne (Cp-ne)mentioning
confidence: 83%