“…A Box-Behnken statistical design with three factors and three levels (Statgraphics software, version 15.2.05, Statgraphics Technologies, Inc., Warrenton, VA, USA) was used to optimize the ICA-Cubs formulations. Based on the available data in the literature, the maximum and minimum levels of the three independent variables (e.g., the active drug ICA, polymer GMO, and P407) were used for the identification of suitable combinations of the drug and polymers using the Quality by Design technique [23,24]. The software generated 17 different batches of different combinations of the drug, GMO, and P407 at their low (−1), medium (0), and high (+1) levels ( Table 1).…”