Formulation and Evaluation of Ciprofloxacin Floating Tablets.

Abstract

Discovery of new polymeric materials suitable for prolonging the drug release, and the improvement in therapeutic efficiency and safety achieved by these delivery systems. Now-a-days the technology of controlled release is also being applied to veterinary products. The aim and objective of our current research is to formulate floating and bio adhesive formulations of ciprofloxacin for its controlled delivery to the duodenum which is its best absorption site, thus the oral bioavailability of ciprofloxacin could be improved by using direct compression technique. The experimental results was revealed that the all formulated tablets were of good quality with regard to hardness (3.7-4 kg/cm2), thickness (0.3-0.35 cm), density (~ 1 g/cm3), weight variation (1.3-4.2) and drug content (> 90%). As the result of floating capability study increasing the effervescent base of tablets from 5% to 10% significantly lower the lag time of floating (From about 6 min to 1.5 min) as well as floating duration (From about 21 hrs to 10 hrs). Invitro drug release showed (Fig. 1) that all formulation released 80% of the ciprofloxacin hydrochloride in 12 hrs study period. It was found that all the formulations were statistically significant (p ≤ 0.05).