Abstract:The objective of the present investigation was to formulate multiparticulate buoyant dosage form of nizatidine, a H2-receptor antagonist widely prescribed in gastric ulcers, duodenal ulcers. The short biological half-life (1 -2 hours), maximum absorption in initial part of small intestine, colonic metabolism of nizatidine favors, development of gastro retentive floating dosage form. Buoyant microspheres of nizatidine were prepared by spray drying technique using hydroxylpropyl methylcellulose and ethylcellulos… Show more
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