Formulation and evaluation of biodegradable microspheres of tinidazole.

Parashar, Vikas; Ahmad, Dabeer; Gupta, Surya Prakash; Upmanyu, Neeraj; Parashar, Neha; Mudgal, Vinod

doi:10.5138/ijdd.2010.0975.0215.02034

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…Melting point determination was done by using melting point apparatus. Small amount of pure drug of Tolbutamide was taken in a capillary tube and it was kept in the melting point apparatus and the melting point was noted [19][20][21][22].…”

Section: B) Melting Pointmentioning

confidence: 99%

Formulation and Evaluation Tolbutamide Liposomes for a Sustained Drug Delivery System

Prajapati

Chatterjee

Bansal

et al. 2022

JBPR

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Novel Drug Delivery system (NDDS) refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects. Applications of liposomes in medicine and pharmacology can be divided into diagnostic and therapeutic applications of liposomes containing various markers or drugs. The aim of the study was to formulate and evaluate Tolbutamide liposomes for a sustained drug delivery system. The tolbutamide was prepared as a liposomal drug delivery system by using two different techniques such as physical dispersion method and ether injection method. The morphological characters of prepared liposomes were determined with the help of optical microscope. The results of the particle size showed, when the concentration of soya lecithin was increased the size of the particle was reduced. The in vitro release showed that as the concentration of soya lecithin was increased the release rate of drug was retarded. Among the two methods ether injection method showed prolonged action when compared to physical dispersion method. The stability studies for all the formulations were performed by keeping the formulations at two different temperatures 4ºC±2ºC and 25ºC±2ºC for a period of 30 days. There was no change in morphological characters at 4ºC±2ºC, but there was a slight reduced in particles size at 25ºC±2ºC. The percentage drug entrapment was reduced in all the formulations at both the conditions.

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Section: B) Melting Pointmentioning

confidence: 99%

Formulation and Evaluation Tolbutamide Liposomes for a Sustained Drug Delivery System

Prajapati

Chatterjee

Bansal

et al. 2022

JBPR

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“…Melting point determination was done by using melting point apparatus. Small amount of pure drug of Metformin HCl was taken in a capillary tube and it was kept in the melting point apparatus and the melting point was noted 10 .…”

Section: B) Melting Pointmentioning

confidence: 99%

Formulation and In-vitro evaluation of liposomal drug delivery system of metformin HCl

Subbramanian¹,

Rani²,

Rajasekaran³

et al. 2019

J. Drug Delivery Ther.

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Metformin is widely used for the treatment of diabetes; the intention of the present study was to formulate Metformin HCl liposomes for a sustained drug delivery system. It have the advantages of dose reduction, less dosing frequency, minimize the side effect, prolong the action of drug and thus achieve better patient compliance. The liposomes were prepared by physical dispersion and ether injection method. Soya lecithin and cholesterol were used for encapsulating the drug, it facilitates to release the medicaments in sustained manner. Chloroform, ether and methanol were used as a solvent. Phosphate buffer pH 6.8 was used as a hydration medium for loading the drug. The final liposome was evaluated in various quality parameters of drug entrapment efficiency, morphological analysis, particle size analysis, in-vitro drug release studies and stability studies. In the two methods of metformin liposome formulation the ether injection method showed prolonged action when compared to physical dispersion method. In the parameters of drug entrapment and stability physical dispersion method was shows better results. Keywords: Physical dispersion, ether injection, soya lecithin, cholesterol, morphological analysis, metformin.

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“…Abdallah et al 19 found that, the mean diameter of the microspheres was increased significantly as the drug: polymer ratio was varied from 1:1 to 1:5. Low concentration of Eudragit RS100 resulted in a low viscosity of the polymer solution which in turn resulted in smaller emulsion droplets in the aqueous phase 20,21 . Also, from the same table, it can be also noticed that, the size range and mean diameter of the products prepared on using 50%, 66.66% or 80% theoretical drug content are nearly double to that prepared on using 20% or 33.33% theoretical drug content products which is in agreement with what stated before about there is a sharp cut in the frequency distribution curve between these products.…”

Section: Determination Of the Actual Drug Contentmentioning

confidence: 99%

Untitled

2014

IJPSR

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Eudragit RS100 microcapsules containing Aspirin as a model drug was prepared using solvent evaporation technique. The drug was dispersed in the organic phase and poured into the aqueous phase with stirring until microcapsules formation. The product was collected by filtration and air dried. The particle size analysis of the products was done and normal distribution curve showed for the same size range of different theoretical drug content, microcapsules had different size distribution. The sphericity of the microcapsule was greatly affected by the theoretical drug loaded. The mean microcapsule size decreased upon increasing the percent of theoretical drug content and then increased again. The surface of spherical microcapsule was smooth and no drug crystals attached to the surface. It was noticed drug crystals in the microcapsule structure. The mean actual drug content was markedly higher than the theoretical one. In the same product prepared with the same theoretical drug content, there was a relationship between the actual drug content and the product particle size. These findings were explained according to the division of emulsified microcapsule during preparation by division mechanism. In this division mechanism, there are two forces; one is the viscosity of the emulsified microcapsule which depends upon the polymer content. This force works against emulsified microcapsule division. The second is the drug solid particle weight in the emulsified microcapsule droplets and the stirring force effect on it which creates and potentiates the division mechanism. These two interacted forces, may be, the controlling factor for the resulting findings.

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Formulation and evaluation of biodegradable microspheres of tinidazole.

Cited by 8 publications

References 5 publications

Formulation and Evaluation Tolbutamide Liposomes for a Sustained Drug Delivery System

Formulation and Evaluation Tolbutamide Liposomes for a Sustained Drug Delivery System

Formulation and In-vitro evaluation of liposomal drug delivery system of metformin HCl

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