Formulation and Evaluation of Antiacne Cream Containing Withania Somnifera

Abstract

Acne vulgaris is a disease of pilosebaceous unit which is characterized by non-inflammatory and inflammatory lesions. Common therapies that are used for the treatment of acne include topical, systemic, hormonal, herbal and combination therapy. So, for the treatment of acne herbal anti acne cream is prepared containing Withania somnifera extract, which is known for its anti-inflammatory action and antioxidant property. Herbal medications are considered safer than allopathic medicines because allopathic medications are associated with different side-effects such as allergy, local irritation, scaling, photosensitivity reaction, itching, peeling, redness etc. The study includes macroscopical and microscopical evaluation of Withania somnifera containing ash value, loss on drying, water extractive value, Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry and Ultraviolet Spectroscopy. The prepared formulation was optimized on the basis of in vitro release study. The optimized formulation was evaluated on the basis of greasiness, spreadability, after feel, skin irritancy, viscosity, pH and release kinetics. Anti bacterial study by disc diffusion technique was performed. The result obtained was zone of inhibition of test 25.66 ± 1.12 and 5.89 ± 1.18 at 500 ppm, this proved that optimized formulation has possible anti acne property. So, further investigation such as in vivo studies will help this formulation to be a potential candidate as marketed product.

A Comprehensive Physical, Spectroscopic, and Thermal Characterization of <i>Withania somnifera</i> (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

“…However, the control and treated ashwagandha indicated the endothermic peak at 203.43°C and 201.67°C, respectively. Several small endothermic peaks also observed in the thermograms of both in the control and treated samples, which may be due to the multiple phytoconstituents present in the ashwagandha root extract in a very small concentration [57,58]. The analysis revealed that there was a lowering of the melting point by 0.87% of the treated sample than the control sample.…”

Evaluation of the Physico-chemical, Thermal and Behavioral Properties of Ashwagandha Root Extract: Effects of Consciousness Energy Healing Treatment

“…However, the Biofield Energy Treated, and control W. somnifera indicated several endothermic peak around 200°C (Figure 7). Several small endothermic peaks were also observed in the thermogram of both in control and treated samples, which may be due to the multiple phytoconstituents present in the root extract in a very small concentration [60,61]. In the Biofield Energy Treated sample the endothermic peak was sharp and significantly prominent as compared to the control sample.…”

Influence of the Biofield Energy Healing Treatment on Physicochemical, Thermal and Behavioral Properties of Ashwagandha (<i>Withania somnifera</i>) Root Extract

“…This evaporation temperature was increased by 1.45%, whereas the latent heat of vaporization significantly increased by 11.30% in in the Biofield Energy Treated sample compared with the control sample (Table 4). Several small endothermic peaks around 180-250°C were also observed in the thermogram of both in control and Biofield Energy Treated samples (Figure 7), which may be due to the multiple phytoconstituents present in the root extract in a very small concentration [60,61].…”