Formulation and evaluation of anise-based bioadhesive vaginal gels

Gafițanu, Carmen; Filip, Daniela; Cernătescu, Corina; Ibănescu, Constanţa; Danu, Maricel; Pâslaru, Elena; Rusu, Daniela; Tuchiluş, Cristina; Macocinschi, Doina

doi:10.1016/j.biopha.2016.06.053

Cited by 14 publications

(10 citation statements)

References 37 publications

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“…The anise crude extracts and active compounds manifest antimicrobial, antioxidant, insecticidal, analgesic, sedative, and convulsive activities ( Wang et al, 2011 ). Anise-based bioadhesive alginate gels for vaginal application showed antibacterial activity, and no effect against Candida species was observed ( Gafiţanu et al, 2016 ). Alginate microparticles containing pomegranate extract ( Punica granatum ) with encapsulation efficiency of 81.9% ( Endo et al, 2012 ) displayed antifungal activity against C. albicans (minimum inhibitory concentration of 3.9 μg/ml), with the advantage of providing controlled extract release to achieve the desired therapeutic effect against oral fungal infection caused by C. albicans ( Endo et al, 2012 ).…”

Section: Alginate-based Delivery Systems For Non-conventional Antifunmentioning

confidence: 99%

Potential Use of Alginate-Based Carriers As Antifungal Delivery System

2017

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Fungal infections have become a major public health problem, growing in number and severity in recent decades due to an increase of immunocompromised patients. The use of therapeutic agents available to treat these fungal infections is limited by their toxicity, low bioavailability, antifungal resistance, and high cost of treatment. Thus, it becomes extremely important to search for new therapeutic options. The use of polymeric systems as drug carriers has emerged as a promising alternative to conventional formulations for antifungals. Alginate is a natural polymer that has been explored in the last decade for development of drug delivery systems due to its non-toxicity, biodegradability, biocompatibility, low cost, mucoadhesive, and non-immunogenic properties. Several antifungal agents have been incorporated in alginate-based delivery systems, including micro and nanoparticles, with great success, displaying promising in vitro and in vivo results for antifungal activities, reduction in the toxicity and the total drug dose used in the treatment, and improved bioavailability. This review aims at discussing the potential use and benefits of alginate-based nanocarriers and other delivery systems containing antifungal agents in the therapy of fungal infections.

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Section: Alginate-based Delivery Systems For Non-conventional Antifunmentioning

confidence: 99%

Potential Use of Alginate-Based Carriers As Antifungal Delivery System

2017

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“…A review of the literature shows that most of these formulations are hydrogels loaded with classical antifungal drugs such as amphotericin B, miconazole or clotrimazole [ 21 , 22 , 23 , 24 , 25 ]. However, other authors have opted to incorporate into their formulations alkannin, diphenyl diselenide, anise or terbinafine, among others [ 26 , 27 , 28 , 29 ]. There are not previous studies reporting the delivery of CSP because is the first time it has been applied topically in vaginal mucosa.…”

Section: Introductionmentioning

confidence: 99%

New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis

Pérez-González

Febrer

Calpena

et al. 2021

Gels

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Vulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of Candida spp. was also evaluated. In addition, tolerance of formulations was studied by histological analysis. Results confirmed that CSP hydrogels could be proposed as promising candidates for the treatment of VVC.

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“…Natural, semisynthetic or synthetic mucoadhesive polymers can be used to form hydrogels. 5) In some case the gels may not be able to provide enough vaginal residence time and controlled release. 6) Therefore new vaginal drug forms with features that are more suitable for this form of drug administering needed to be developed.…”

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confidence: 99%

Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels

Tuğcu-Demiröz

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Liposomal vaginal drug delivery systems are important strategy in the treatment of both topical and systemic diseases. The aim of this study was to develop a vaginal delivery system for benzydamine hydrochloride (BNZ) loaded liposomes dispersed into mucoadhesive gels. The delivery system was also designed for a once a day dosage and to obtain controlled release of the BNZ. For this purpose BNZ containing gel formulations using hydroxypropyl methylcellulose (

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Formulation and evaluation of anise-based bioadhesive vaginal gels

Cited by 14 publications

References 37 publications

Potential Use of Alginate-Based Carriers As Antifungal Delivery System

Potential Use of Alginate-Based Carriers As Antifungal Delivery System

New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis

Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels

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