Formulation and Evaluation of a New Biodegradable Periodontal Chip Containing Thymoquinone in a Chitosan Base for the Management of Chronic Periodontitis

Abstract

Objective.This study was performed to develop a biodegradable periodontal chip containing thymoquinone and to evaluate its effectiveness for managing chronic periodontitis.Methods.Chips were formulated from thymoquinone and chitosan. Twelve patients with periodontal pockets measuring ≥5 mm participated in this study. Overall, 180 periodontal pockets were evaluated. At day zero, all patients were treated with full-mouth scaling and root planning. Periodontal pockets were divided into three groups. Group one served as the control group, while group two received plain chitosan chips. Group three received chips containing thymoquinone. Plaque index, bleeding upon probing, periodontal probing pocket depths, and clinical attachment levels were recorded at days 0 and 60.Results.The statistical significance of differences was tested with a paired samplet-test, a Chi-squared test, and a one-way ANOVA. The results indicated significant improvement in plaque index and bleeding upon probing and a reduction in periodontal pockets from baseline in all four groups(P<0.05). Gains in clinical attachment levels were significantly higher(P<0.005)in the group receiving thymoquinone chips compared to other groups.Conclusion.Periodontal chips containing thymoquinone can be used as adjuncts for the treatment of patients with chronic periodontitis.

In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention

“…Several studies have investigated the medicinal effect of the N. sativa extract in different dental applications [ 46 , 47 , 48 , 49 ]. Omar et al [ 47 ] evaluated N. sativa oil as pulp capping medicaments in pediatric dentistry using the animal model.…”

“…Thymoquinone (TQ) is the major ingredient in N. sativa seed essential oil, which has been proved to have broad medical benefits [ 43 , 44 , 45 ]. In addition, N. sativa seed extract has been tested recently in the dental field for a potential therapeutic effect against dental caries [ 46 ], pulpal diseases [ 47 ], gingival and periodontal diseases [ 48 ], and oral ulcerations [ 49 ].…”

Effectiveness of Thymoquinone and Fluoridated Bioactive Glass/Nano-Oxide Contained Dentifrices on Abrasion and Dentine Tubules Occlusion: An Ex Vivo Study

“…12 Also, in recent times, considerable research has been done on using various types of plant extracts such as Azadirachta indica, Salvadore persica, and Nigella sativa in dentistry. [13][14][15] N. sativa contains thymoquinone having antibacterial and anti-inflammatory properties and could reduce dental caries and prevent periodontal and gingival diseases. 16 The bioceramics have certain abrasivity and it needed to be evaluated to prevent the wear of hard tissues, that is, enamel and dentin.…”

Fabrication of Thymoquinone‐Loaded Albumin Nanoparticles by Microfluidic Particle Synthesis and Their Effect on Planarian Regeneration

“…In addition to poor solubility, thermal‐ and light‐sensitive nature of TQ causes stability problems . To overcome these limitations, different drug delivery systems such as liposomes, and niosomes, as well as poly(lactic‐ co ‐glycolic acid) (PLGA), chitosan, or cyclodextrin nanoparticles have been used.…”