Formulation and evaluation of a two-stage targeted liposome coated with hyaluronic acid for improving lung cancer chemotherapy and overcoming multidrug resistance

Wang, Xuelian; Cai, Hongye; Huang, Xinyu; Lu, Zhuhang; Zhang, Luxi; Hu, Junjie; Tian, Daizhi; Fu, Jiyu; Zhang, Guizhi; Meng, Yan; Zheng, Guohua; Chang, Cong

doi:10.1080/09205063.2023.2201815

Cited by 3 publications

(1 citation statement)

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“…Previously, our research group investigated the mitochondrial targeting of liposomes modified with triphenylphosphonium cationic amphiphiles with different lengths of hydrocarbon tails and at different ratios of amphiphiles/lipids in the case of cancer [ 51 ]. In addition to oncological diseases [ 52 , 53 , 54 ], the mitochondria-targeted drug delivery strategy is gaining more importance in the context of such disorders as retinal ischemia–reperfusion injury [ 55 ], cardiovascular diseases [ 56 ], stress-related neurodegenerative diseases [ 57 , 58 , 59 ], etc. It is worth noting that in the above cases and in many others, the key role in pathogenesis is played by dysregulation of the production of reactive oxygen species, for which the mitochondria of cells are responsible [ 60 , 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer’s Disease Therapy

Васильева

Gaynanova

Валеева

et al. 2023

IJMS

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Liposomes modified with tetradecyltriphenylphosphonium bromide with dual loading of α-tocopherol and donepezil hydrochloride were successfully designed for intranasal administration. Physicochemical characteristics of cationic liposomes such as the hydrodynamic diameter, zeta potential, and polydispersity index were within the range from 105 to 115 nm, from +10 to +23 mV, and from 0.1 to 0.2, respectively. In vitro release curves of donepezil hydrochloride were analyzed using the Korsmeyer–Peppas, Higuchi, First-Order, and Zero-Order kinetic models. Nanocontainers modified with cationic surfactant statistically better penetrate into the mitochondria of rat motoneurons. Imaging of rat brain slices revealed the penetration of nanocarriers into the brain. Experiments on transgenic mice with an Alzheimer’s disease model (APP/PS1) demonstrated that the intranasal administration of liposomes within 21 days resulted in enhanced learning abilities and a reduction in the formation rate of Aβ plaques in the entorhinal cortex and hippocampus of the brain.

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