Formulation and Development of Voriconazole Tablets Containing Solid Dispersion With Enhanced Solubility, Dissolution and Bioavailability
Atish B. Velhal,
Vijay R. Salunkhe
Abstract:This research work enhances the solubility, dissolution and bioavailability of Voriconazole which belongs to BCS II class. Carboxymethyl tamarind gum was synthesized by using carboxymethylation of tamarind gum. Solid dispersion of Voriconazole was developed by kneading method followed by immediate release tablets. Solid dispersion characterised for solubility and instrumental analysis. Tablets were evaluated for dissolution study. Solid dispersions were confirmed by presence of distinctive peaks at 1745.58 cm-… Show more
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