Formulation and development of herbal microsponge sunscreen gel

Abstract

Purpose The endeavor of this study is to prepare and developed a method for microsponge gel as a polyherbal formulation along with their evaluation methods for sunscreen properties. Method Polyherbal extracts as an active component for preparing microsponge formulation used in ratio of a drug, i.e. Poly herbal extracts, ethyl cellulose used as polymer, Polyvinyl alcohol as an emulsifier present in the formulation was successfully obtained by using method quasi‐emulsion solvent diffusion. The formulations prepared were considered for substantial characterization. The physical description of microsponge formulation, having a coating of Gel‐3 exhibits more loading efficiency and production yield. The mentioned formulation of microsponge was formulated with the help of gel using carbopol and then test performed are pH, viscosity, spreadability, drug content, and in‐vitro release. Most of the microsponge preparations are prepared by drug loading in it and the consequences are good to reproduce. The best formulation was prepared and then comparison study was done with one of the marketed simple gel of polyherbal extract and other one is microsponge loaded gel of polyherbal extract by using Franz diffusion cell. Result The release profile details about that the microsponge loaded gels are showing excellent release rate while comparing to simple marketed gel of polyherbal extract.

Preclinical evaluation from in‐silico to in‐vivo study of polyherbal microsponge sunscreen gel

“…All the chemicals used in this study were of analytical grade. Microsponges were prepared using the quasi‐emulsion solvent diffusion technique 9 Animal used—Albino rats (Wister strain) Bodyweight—175 to 200 g Days during the experimental break—30 days Cage Temperature—25 ± 2°C Relative humidity—60 ± 5% …”

“…Some of the already published microsponge controlled release formulations are benzyl peroxide, mupirocin, retinoid, 5‐fluorouracil, etc., but because of several drawbacks caused by using chemical substances like photoinstability and adverse effects of chemical filters, the formulation that uses herbal extracts is choice of interest nowadays 8 . In the current scenario, manufacturers use different herbal components in the preparation of skin protection formulations from UV rays 9 . Polyherbal extracts comprising of three or more plant extracts were prepared and utilized for the gel formulation which is supposed to act by whole radiation's absorption in the range 280–315 nm and mimics the energy preservation law.…”

“…8 In the current scenario, manufacturers use different herbal components in the preparation of skin protection formulations from UV rays. 9 Polyherbal extracts comprising of three or more plant extracts were prepared and utilized for the gel formulation which is supposed to act by whole radiation's absorption in the range 280-315 nm and mimics the energy preservation law. In the present study, the formulation consisting of polyherbal was evaluated by the in-vivo studies and the active constituents were used for the in-silico toxicity as well as the in-vitro anti-oxidant studies.…”

Formulation and Evaluation of Herbal Sunscreens: An Assessment Towards Skin Protection from Ultraviolet Radiation

“…Genuine herbal elements in sun-screen are the least irritating to the skin, especially for sensitive skin [6], include natural components, can regenerate the skin, and give enough protection against pollution and climate changes in the atmosphere. The most often used herbs in natural sunscreen include aloe vera, vitamin E, turmeric, and cucumber [7][8][9]. Aloe vera is a well-known and ancient Liliaceae medicinal plant.…”

Herbal microsponge incorporated sunscreen gel: A novel strategy

“…They are capable of absorbing skin secretions; thus, the oiliness of the skin can be reduced. Being inert, very small in size, and indestructible spheres, microsponges are not able to penetrate through skin (1).…”