Formulation and design optimization of nano-transferosomes using pioglitazone and eprosartan mesylate for concomitant therapy against diabetes and hypertension

Ramkanth, S; Anitha, P.; Gayathri, R.; Mohan, S.; Babu, Dinesh

doi:10.1016/j.ejps.2021.105811

Cited by 31 publications

(14 citation statements)

References 40 publications

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“…It is worthy of note that nanoscale transdermal delivery systems have found a place in many areas of medicine, and their usage is not limited to the treatment of local skin diseases or inflammatory processes. There are studies on the application of such systems for the treatment of diabetes and cardiovascular diseases [273].…”

Section: Discussionmentioning

confidence: 99%

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

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This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.

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Section: Discussionmentioning

confidence: 99%

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

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“…Similarly, the OTP was estimated for in vitro diffusion studies for 24 h at periodic time intervals. The results were fitted to various kinetic studies [ 34 ]. The diffusion study was carried out in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Box–Behnken Design: Optimization of Proanthocyanidin-Loaded Transferosomes as an Effective Therapeutic Approach for Osteoarthritis

Tamilarasan

Begum

Anitha³

et al. 2022

Nanomaterials

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Transferosomes are one of the vesicular carriers that have received extensive research and attention recently because of their capacity to get beyond the barriers posed by the stratum corneum to penetration. The intent of the current study is to optimize and evaluate proanthocyanidin (PAC) containing transferosomal transdermal gels. PAC-containing transferosomes were prepared using the film hydration method and then loaded into a 4% methylcellulose gel. A 23 Box–Behnken design was used to optimize the PAC-loaded transferosomal gel, where the effects of phospholipid 90 G (X1), Tween 80 (X2), and sonication time (X3) were evaluated. The formulation factors, such as the drug entrapment efficiency percentage (PEE) and in vitro drug release, were characterized. A PEE of 78.29 ± 1.43% and a drug release in vitro at 6 h of 24.2 ± 1.25% were obtained. The optimized transferosomal-loaded proanthocyanidin (OTP) formulation penetrated the porcine skin at an excellent rate (0.123 ± 0.0067 mg/cm2/h). Stability tests were conducted for OTP to predict the effects of various temperature conditions on the physical appearance, drug content, and PEE for periods of 15, 30, and 45 days. Finally, this transferosomal system for transdermal PAC delivery may be a suitable alternative to the conventional treatment for osteoarthritis.

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“…as the main component, single chain surfactant in a range of 10–25%, alcohol as solvent (3–10%), and phosphate buffered saline (pH 6.5–7) [ 116 ]. For the latest applications, transferosomes have been successfully used for the transdermal delivery of both low- and high-molecular-weight drugs such as insulin [ 117 ], pioglitazone and eprosartan mesylate codelivery [ 118 ], minoxidil [ 118 ], vancomycin hydrochloride [ 119 ] and tapentadol [ 113 ].…”

Section: Lipid Nanosystems Utilized In Skin Deliverymentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

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Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritation. These limitations can be overcome by employing new approaches such as lipid nanosystems. Due to their advantages (such as easy scaling, low cost, and remarkable stability) these systems have attracted interest from the scientific community. However, for a successful formulation, several factors including particle size, surface charge, components, etc. have to be understood and controlled. This review provided a brief overview of the structure of the skin as well as the different pathways of nanoparticle penetration. In addition, the main factors influencing the penetration of nanoparticles have been highlighted. Applications of lipid nanosystems for dermal and transdermal delivery, as well as regulatory aspects, were critically discussed.

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Formulation and design optimization of nano-transferosomes using pioglitazone and eprosartan mesylate for concomitant therapy against diabetes and hypertension

Cited by 31 publications

References 40 publications

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

Box–Behnken Design: Optimization of Proanthocyanidin-Loaded Transferosomes as an Effective Therapeutic Approach for Osteoarthritis

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

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