Formulation and design of sustained release matrix tablets of metformin hydrochloride: Influence of hypromellose and polyacrylate polymers

Abstract

Aim:The current paper was an attempt to design a sustained release dosage form using various grades of hydrophilic polymers, Hypromellose (hydroxyl-propyl methylcellulose [HPMC] K15M, HPMC K100M and HPMC K200M) and Polyacrylate polymers, Eudragit RL100 and Eudragit RS100 with or without incorporating ethyl cellulose on a matrix-controlled drug delivery system of Metformin hydrochloride.Materials and Methods:Laboratory scale batches of nine tablet formulations were prepared by wet granulation technique (Low shear). Micromeritic properties of the granules were evaluated prior to compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, drug content or assay and evaluated for in-vitro release pattern for 12 h using Phosphate buffer of pH 6.8 at 37 ± 0.5°C. The in-vitro release mechanism was evaluated by kinetic modeling.Results and Discussion:The results obtained revealed that HPMC K200M at a concentration of 26% in formulation (F6) was able to sustain the drug release for 12 h and followed the Higuchi pattern quasi-Fickian diffusion. With that, combined effect of HPMC K15M as an extragranular section and Eudragit RS100 displayed a significant role in drug release. Dissolution data were compared with innovator for similarity factor (f2), and exhibited an acceptable value of ≥50 Three production validation scale batches were designed based on lab scale best batch and charged for stability testing, parameters were within the limit of acceptance. There was no chemical interaction found between the drug and excipients during Fourier Transform Infrared Spectroscopy (FTIR) and Differential scanning calorimetry study.Conclusion:Hence, combinely HPMC K200M and Eudragit RS100 at a suitable concentration can effectively be used to sustain drug release.

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

“…The in vitro release studies of the above system indicated that the combination of this material may modify the dissolution rate 39 . An extended release tablet containing metformin was successfully prepared via melt granulation combining the hydrophobic stearic acid and hydrophilic poly(ethylene oxide).…”

Native and microwave-modified Terminalia mantaly gums as sustained-release and bioadhesive excipients in naproxen matrix tablet formulations

“…Generally, sustained-release dosage forms provide better control of drug levels in plasma, reduce dosage frequency and increase therapeutic efficacy through steady drug delivery. 4 The bioadhesive property of certain polymeric systems has found relevance in drug delivery as a means of prolonging contact time in the various mucosal routes of drug administration. The ability to maintain a delivery system at a particular location for an extended period of time has great appeal for local action as well as systemic drug bioavailability.…”

Polymers in Drug Delivery Technology, Types of Polymers and Applications

“…The most commonly used water insoluble polymers for extended release applications are the ammonium ethacrylate copolymers cellulose derivatives ethyl cellulose and cellulose acetate, and polyvinyl derivative, polyvinyl acetate [15,17,20].…”