Formulation and conservation of a pharmaceutical form with leaf extracts from Acacia aroma Gill. ex Hook et Arn

Abstract

Leaf fluid extracts of Acacia aroma GILL. ex Hook et Arn showed antibacterial activity against antibiotic multiresistant bacteria isolated from clinical samples, antioxidant and ant-inflammatory activities. Toxicological studies carried out on Artemia salina and Allium cepa attested none toxicity potential. The aim of this work was to elaborate a formulation of topical antibacterial hydrogel with Carbopol acrylic acid polymer containing an A. aroma fluid extract in order to compare with a hydrogel containing commercial antibiotic. The optimal extract concentration in this formulation was determined according to the values of minimal inhibitory concentration and minimal bactericidal concentration for Staphylococcus aureus, methicillin-resistant (F7) and Pseudomonas aeruginosa (F352). Physical, chemical, rheological and microbiological stability was observed at least during one year. The hydrogel containing Acacia leaves fluid extract shows remarkable antibacterial effect with a broadspectrum efficacy against Gram positive and Gram negative bacteria at low concentration.

Evaluation of a preservative system in a gel containing hydroalcoholic extract of Schinus terebinthifolius

“…Leal et al (1996) studied the antimicrobial activity of gelled forms of Schinus terebinthifolius used for vaginal treatments, showing their efficacy against S. aureus. Subsequent studies have confirmed this activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Aspergilus niger in different gels (Amorim & Santos, 2003Melo Jr. et al, 2003Arias et al, 2004).…”