Formulation and clinical evaluation of mucoadhesive buccal films containing hyaluronic acid for treatment of aphthous ulcer

Abo-shady, Anowaar Z.; El-kammar, Hala A.; Elwazzan, Vivian S.; Nasr, Mohamed

doi:10.1016/j.jddst.2019.101442

Cited by 14 publications

(9 citation statements)

References 29 publications

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“…It is widely present in the cytoplasm and has good biocompatibility [42]. HA is one of the main components of the extracellular matrix, which plays an important role in promoting the formation of blood clots, 5 Computational and Mathematical Methods in Medicine angiogenesis, proliferation and migration of fibroblasts, regeneration of granulation tissue, and other biological processes after the occurrence of wounds or ulcers in the human body [42,43] and can play a role in moisturizing, promoting wound healing, and regulating immune inflammatory response. Therefore, exogenous HA supplementation has a high application value in the treatment of DFU.…”

Section: Discussionmentioning

confidence: 99%

A Net Meta-Analysis of the Effectiveness of Different Types of Dressings in the Treatment of Diabetic Foot

Wang

Chen

Yin

2022

Computational and Mathematical Methods in Medicine

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Objective. This is an analysis of the impact of a new dressing commonly used to treat diabetic foot (DFU). Methods. Chinese and English databases were searched to collect clinical randomized controlled studies (RCTs) of various types of dressings for the treatment of DFU, and the healing rates of the different dressings were combined by reticulation meta-analysis. Results. The aggregate of the 36 RCTs included in this study analysed the healing rates of nine dressings: conventional dressing, alginate dressing, chitosan dressing, hyaluronic acid dressing, platelet-rich plasma dressing, amniotic membrane dressing, honey dressing, human recombinant growth factor dressing, and silver ionomer dressing. Conclusion. Hyaluronic acid dressing, amniotic membrane dressing, honey dressing, and platelet-rich plasma dressing are the ideal materials for topical treatment of DFU.

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Section: Discussionmentioning

confidence: 99%

A Net Meta-Analysis of the Effectiveness of Different Types of Dressings in the Treatment of Diabetic Foot

Wang

Chen

Yin

2022

Computational and Mathematical Methods in Medicine

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“…The increased bioadhesion values were observed while using the higher level of HA. This may be due to obtaining higher surface area by increasing polymer concentration (14).…”

Section: Resultsmentioning

confidence: 99%

“…Hyaluronic acid (HA) is a biodegradable, biocompatible, non-immunogenic, and mucoadhesive linear polysaccharide of D-glucuronic acid and N-acetyl-Dglucosamine (11)(12)(13). It provides tissue healing for oral ulcers by activating the inflammatory responses, promoting cell growth, and re-epithelization (14). The objective of the current study was to develop a buccal film containing BNZ as an active compound.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization, and In-Vitro Evaluation of Hyaluronic Acid Buccal Films Containing Benzydamine Hydrochloride

Karakucuk¹,

Tort²

2021

Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Aim: Mucoadhesive buccal films provide drug delivery for both local and systemic circulation with increased patient compliance. The objective of this study was to develop a buccal film containing benzydamine hydrochloride (BNZ) by using hyaluronic acid (HA) as a film-forming agent and glycerin (Gly) as a plasticizer for the anti-inflammatory effect on the mucosal ulcer. Material and Methods: The effects of different concentrations of HA and Gly on responses were analyzed using 2 3 factorial design. The HA and Gly ratio were selected as independent factors, and work of mucoadhesion, tensile strength, elongation at break, and contact angle values were chosen as dependent factors. Nine different film formulations were prepared at constant BNZ concentration (0.15%) by solvent casting method. Mechanical and mucoadhesion properties of film formulations were evaluated, and also contact angles were calculated. The BNZ release profiles were evaluated in simulated saliva solution (pH 6.8). Results: All film formulations were successfully prepared by solvent casting method. Increasing HA concentration from 0.5 to 2 % raised the mechanical and mucoadhesion properties of film formulations. Although the addition of Gly decreased the tensile strength values, it increased the elongation at break values about ten times. All formulations released more than 60 % BNZ in 60 mins. Conclusion:It is concluded that HA oral mucoadhesive film formulations containing BNZ are promising for treating oral ulcers.

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Section: Electrospinning In the Treatment Of Oral Ulcersmentioning

confidence: 99%

“…HA has been shown to provide anti-inflammatory and mucosal adhesion [ 108 ]. HA can be used for skin tissue regeneration [ 133 ].…”

Section: Electrospinning In the Treatment Of Oral Ulcersmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

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Formulation and clinical evaluation of mucoadhesive buccal films containing hyaluronic acid for treatment of aphthous ulcer

Cited by 14 publications

References 29 publications

A Net Meta-Analysis of the Effectiveness of Different Types of Dressings in the Treatment of Diabetic Foot

A Net Meta-Analysis of the Effectiveness of Different Types of Dressings in the Treatment of Diabetic Foot

Formulation, Optimization, and In-Vitro Evaluation of Hyaluronic Acid Buccal Films Containing Benzydamine Hydrochloride

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

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