Formulation and characterization of sustained release dosage form of moisture sensitive drug

Patel, Priya; Dave, Abhishek; Vasava, Amit; Patel, Paresh U.

doi:10.4103/2230-973x.153385

Cited by 14 publications

(12 citation statements)

References 5 publications

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“…Hardness [14] The resistance of tablets to shipping or breakage under condition of storage, transportation and handling before usage depends on its hardness. The hardness of each batch of tablet was checked by using Monsanto hardness tester.…”

Section: Evaluation Of Prepared Formulationsmentioning

confidence: 99%

Formulation and evaluation of bi-layered tablet of divalproex sodium

Khan¹,

Prasad²,

Dubey³

2023

J Pharmacogn Phytochem

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Objective: To Formulate and Evaluate bi-layered tablet of Divalproex Sodium. Method: Divalproex sodium is broad-spectrum anticonvulsant. It increases the availability of gammaamino butyric acid (GABA), an inhibitory neurotransmitter, The bilayer tablet of Divalproex sodium were prepared by using sodium starch glycolate, croscarmellose sodium, lactose, microcrystalline cellulose, polyvinyl pyrrolidone, magnesium stearate, talc, hydroxyl propyl methyl cellulose, as Excipents using wet granulation by using different Superdisintegrants. Result: In the present work, formulation and evaluation of bi-layered tablet of Divalproex sodium was carried out. In the project, different formulations of immediate release and sustained release layer have been prepared separately. From above formulations best formulation of each immediate and sustained release layers were selected according to the dissolution profile and bi-layered tablet were prepared. Conclusion:In the present work bi-layered tablet of Divalproex sodium were prepared by wet granulation method, using super disintegrants such as sodium starch glycolate and croscarmellose for immediate release layer and polymer like HPMC K4M and HPMC K100M for sustained release layer. Best formulations of each layer were selected for bi-layered tablet and bi-layered tablet were prepared. Bi-layered tablet of Divalproex sodium were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction.

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Section: Evaluation Of Prepared Formulationsmentioning

confidence: 99%

Formulation and evaluation of bi-layered tablet of divalproex sodium

Khan¹,

Prasad²,

Dubey³

2023

J Pharmacogn Phytochem

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“…An example is the combination of hydrophilic commercial polymers Eudragit ® E PO and Eudragit ® RLPO for the coating of moisture-sensitive ranitidine hydrochloride, a treatment for gastroesophageal reflux disease. The coated tablets displayed superior moisture protection over its marketed formulation RANTEC 300, where it gained only 10–15% moisture compared with 35–40% in RANTEC300 after 170 h in 75%RH, proving the effectiveness of hydrophilic polymer combinations as moisture-protective barriers [ 34 ].…”

Section: Formulation Strategies To Reduce or Control Hygroscopicitymentioning

confidence: 99%

Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly Hygroscopic Pharmaceuticals and Nutraceuticals

Ling

Hadinoto

2022

Pharmaceutics

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Highly hygroscopic pharmaceutical and nutraceutical solids are prone to significant changes in their physicochemical properties due to chemical degradation and/or solid-state transition, resulting in adverse effects on their therapeutic performances and shelf life. Moisture absorption also leads to excessive wetting of the solids, causing their difficult handling during manufacturing. In this review, four formulation strategies that have been employed to tackle hygroscopicity issues in oral solid dosage forms of pharmaceuticals/nutraceuticals were discussed. The four strategies are (1) film coating, (2) encapsulation by spray drying or coacervation, (3) co-processing with excipients, and (4) crystal engineering by co-crystallization. Film coating and encapsulation work by acting as barriers between the hygroscopic active ingredients in the core and the environment, whereas co-processing with excipients works mainly by adding excipients that deflect moisture away from the active ingredients. Co-crystallization works by altering the crystal packing arrangements by introducing stabilizing co-formers. For hygroscopic pharmaceuticals, coating and co-crystallization are the most commonly employed strategies, whereas coating and encapsulation are popular for hygroscopic nutraceuticals (e.g., medicinal herbs, protein hydrolysates). Encapsulation is rarely applied on hygroscopic pharmaceuticals, just as co-crystallization is rarely used for hygroscopic nutraceuticals. Therefore, there is potential for improved hygroscopicity reduction by exploring beyond the traditionally used strategy.

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“…Many efforts have been made to develop effective formulations and maintain product stability of ranitidine hydrochloride [ 82 ]. Patel et al [ 83 ] reported that film coating using a combination of Eudragit ® EPO and Eudragit ® RLPO was effective in improving moisture stability and enhancing therapeutic efficacy of ranitidine hydrochloride [ 83 ].…”

Section: Pharmaceutical Application Of Film Coatingmentioning

confidence: 99%

Pharmaceutical Application of Tablet Film Coating

et al. 2020

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Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven process and the evolution of coated dosage forms relies on advancements in coating technology, equipment, analytical techniques, and coating materials. Although multiple coating techniques are developed for solvent-based or solvent-free coating processes, each method has advantages and disadvantages that may require continuous technical refinement. In the film coating process, intra- and inter-batch coating uniformity of tablets is critical to ensure the quality of the final product, especially for active film coating containing active pharmaceutical ingredients in the coating layer. In addition to experimental evaluation, computational modeling is also actively pursued to predict the influence of operation parameters on the quality of the final product and optimize process variables of tablet film coating. The concerted efforts of experiments and computational modeling can save time and cost in optimizing the tablet coating process. This review provides a brief overview of tablet film coating technology and modeling approaches with a focus on recent advancements in pharmaceutical applications.

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Formulation and characterization of sustained release dosage form of moisture sensitive drug

Cited by 14 publications

References 5 publications

Formulation and evaluation of bi-layered tablet of divalproex sodium

Formulation and evaluation of bi-layered tablet of divalproex sodium

Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly Hygroscopic Pharmaceuticals and Nutraceuticals

Pharmaceutical Application of Tablet Film Coating

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