Formulation and characterization of ketoprofen liquisolid compacts by Box-Behnken design

Vittal, G Vijayaranga; Deveswaran, R.; Srinivasan, Bharath; Basavaraj, B. V.; Madhavan, V.

doi:10.4103/2230-973x.104398

Cited by 35 publications

(5 citation statements)

References 3 publications

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“…Samples Blank_E (CI 27.54%, HR 1.38), PrunusP_W (CI 22.95%, HR 1.23) and Rubus_W (CI 26.05%, HR 1.26) showed poor flow character. Finally, all the measured values of powder blends were comparable with other studies (CI 11-30%, HR 1.1-1.4), although they used chemically uniform drugs and different solvents [37,43]. The powder blends with the extract Rubus fruticosus showed cohesive forces (more pronounced in this plant extract [44]), increasing the HP and CI.…”

Section: Evaluation Of the Powder Blendssupporting

confidence: 84%

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

et al. 2022

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A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium aluminometasilicates, silica aerogels, mesoporous silicates, clays, etc. In this study, magnesium aluminometasilicate is used to prepare modified LSS formulations with plant extracts as model drugs dissolved in water (W) or ethanol (E). The modification involves drying tablets in a microwave (MW) and hot air dryer (HA) for a specified period. Powder blends and tablets were evaluated for physical properties, and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). PLS and ANOVA were used to compare tablets properties depending on the composition and technology. The experiment is based on a previous one, in which the plant extracts were processed into tablets using a similar method. Therefore, extending the study to include more plants and the robust statistical evaluation and comparison of the products was a procedure to justify the suitability of the presented method for a wide range of liquid plant extracts. As a result, we obtained tablets with excellent physical properties, including a short disintegration and dissolution, which is problematic in tableted extracts.

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Section: Evaluation Of the Powder Blendssupporting

confidence: 84%

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

et al. 2022

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“…The size distribution, shape, as well as particle size of the microspheres are ascertained using the following techniques [6].…”

Section: Morphology Of the Particlesmentioning

confidence: 99%

Formulation and evaluation of cidofovir loaded microspheres

et al. 2024

Int. J.Exp. Biomed. Res.

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The study aimed to produce and assess cidofovir microspheres using the emulsion solvent diffusion method. Microspheres loaded with ethyl cellulose and HPMC were prepared. FTIR analysis confirmed stability with no drug-polymer interaction, and compatibility investigations ensured formulation compatibility. SEM determined particle size, with yields ranging from 84.44% to 87.62% and drug content from 64.8% to 97.2%. Particle sizes ranged from 20 µm to 210 µm, with drug loading capacities of 55.6% to 96.8% and entrapment efficiencies of 55.5% to 89.1%. Swellability studies showed a range of 0.6 to 1.6 seconds. Formulation CM8 exhibited optimal dissolution in vitro at 62.87%. Drug dissolution data were fitted to various models, with R2 values ranging from 0.937 to 0.061. Up to 45 minutes of drug release was observed. Overall, cidofovir-loaded HPMC and ethyl cellulose microspheres showed favorable release properties under optimal conditions.

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“…A liquisolid formulation allows an insoluble drug to be solubilized, almost molecularly dispersed in a solid dosage form, which greatly enhances the dissolution rate of solubility-limiting drugs due to ameliorative wetting property and dissolution surface area, hence the oral bioavailability. There a great number of poorly water-soluble drugs have been developed into liquisolid formulations in an attempt to enhance their dissolution and/or bioavailability, including Rosuvastatin [ 195 ], Aprepitant [ 217 ], Fenofibrate [ 218 ], Curcumin [ 198 ], Indomethacin [ 219 ], Griseofulvin [ 205 ], Loperamide [ 208 ], Ketoprofen [ 220 ], Olmesartan Medoxomil [ 207 ], Loratadine [ 221 ], Nimesulide [ 222 ], Furosemide [ 223 ], Lovastatin [ 224 ], Carbamazepine [ 203 ], Telmisartan [ 200 ], Valsartan [ 225 ], and Mosapride Citrate [ 196 ].…”

Section: Liquisolid Dispersion Techniquementioning

confidence: 99%

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs

et al. 2018

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Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients. Poorly water-soluble drugs, especially biopharmaceutical classification system (BCS) II ones, are preferably designed as oral dosage forms if the dissolution limit can be broken through. Minimizing a drug’s size is an effective means to increase its dissolution and hence the bioavailability, which can be achieved by specialized dispersion techniques. This article reviews the most commonly used dispersion techniques for pharmaceutical processing that can practically enhance the dissolution and bioavailability of poorly water-soluble drugs. Major interests focus on solid dispersion, lipid-based dispersion (nanoencapsulation), and liquisolid dispersion (drug solubilized in a non-volatile solvent and dispersed in suitable solid excipients for tableting or capsulizing), covering the formulation development, preparative technique and potential applications for oral drug delivery. Otherwise, some other techniques that can increase the dispersibility of a drug such as co-precipitation, concomitant crystallization and inclusion complexation are also discussed. Various dispersion techniques provide a productive platform for addressing the formulation challenge of poorly water-soluble drugs. Solid dispersion and liquisolid dispersion are most likely to be successful in developing oral dosage forms. Lipid-based dispersion represents a promising approach to surmounting the bioavailability of low-permeable drugs, though the technique needs to traverse the obstacle from liquid to solid transformation. Novel dispersion techniques are highly encouraged to develop for formulation of poorly water-soluble drugs.

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Formulation and characterization of ketoprofen liquisolid compacts by Box-Behnken design

Cited by 35 publications

References 3 publications

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

Formulation and evaluation of cidofovir loaded microspheres

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs

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