Formulation and Characterization of Intranasal Drug Delivery of Frovatriptan-Loaded Binary Ethosomes Gel for Brain Targeting

Hamzah, Mohammed; Kassab, Hanan

doi:10.2147/nsa.s442951

Cited by 5 publications

(1 citation statement)

References 62 publications

(89 reference statements)

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“…This innovative technique involves combining NE with a gel to boost its stability and enable the quick and controlled release of the drug [ 36 , 37 ]. The attention toward nanoemulgel has grown due to its capacity for precise administration, convenient application, lack of degradation in the gastrointestinal tract or initial metabolism, and favorable safety profile [ 36 , 38 ]. Nanoemulgel is a topically applied formulation that is based on emulsion.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Dipyridamole- and Roflumilast-Loaded Nanoemulsion and Nanoemulgel for Enhanced Skin Permeation: Formulation, Characterization, and In Vitro Assessment

Maded,

Sfar,

Taqa

et al. 2024

Pharmaceuticals

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This study explores developing and optimizing a nanoemulsion (NE) system loaded with dipyridamole and roflumilast, aiming to improve skin penetration and retention. The NE formulation was further transformed into a nanoemulgel to enhance its application as a topical treatment for psoriasis. Solubility studies were conducted to select the oil, surfactant, and co-surfactant. Phase diagrams were constructed using the aqueous phase titration method. All the formulations were in nanoscale, and Formula (F2) (which contains oleic acid oil as the oil phase, a mixture of Surfactant Tween 80 and co-surfactant (ethanol) at a ratio of 1:2 in addition to distilled water as an aqueous phase in a ratio of 1:5:4, respectively) was the selected formula depending on the particle size, PDI, and zeta potential. Formula (F2) has the best ratio because it gives the smallest nanoemulsion globule size (particle size average of 167.1 nm), the best homogenicity (lowest PDI of 0.195), and the highest stability (higher zeta potential of −32.22). The selected formula was converted into a nanoemulgel by the addition of 0.5% (w/w) xanthan gum (average particle size of 172.7 nm) and the best homogenicity (lowest PDI of 0.121%) and highest stability (higher zeta potential of −28.31). In conclusion, the selected formula has accepted physical and chemical properties, which enhanced skin penetration.

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Section: Introductionmentioning

confidence: 99%

Development and Optimization of Dipyridamole- and Roflumilast-Loaded Nanoemulsion and Nanoemulgel for Enhanced Skin Permeation: Formulation, Characterization, and In Vitro Assessment

Maded,

Sfar,

Taqa

et al. 2024

Pharmaceuticals

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Ethosomes: a potential nanovesicular carrier to enhancing the drug delivery against skin barriers

Hameed,

Faheem,

Khan

et al. 2024

Journal of Microencapsulation

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Quality by Design Enables Formulation Development of Zolmitriptan Loaded Ethosomal Intra-Nasal Gel for Brain Targeting: In Vitro and Ex Vivo Evaluation

NERELLA,

VASUDHA

2024

Int J App Pharm

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Objective: Although zolmitriptan's 50% oral bioavailability and recurrence of migraine-associated disorders make it one of the most essential drugs for managing the illness, adverse effects linked to dosage are still a concern. A unique intra-nasal brain targeting strategy may significantly extend the drug's residence duration at the absorption site and resolve the current problems. Methods: To effectively adjust the drug's residence via the intra-nasal route, the current study focuses on the development of zolmitriptan-loaded ethosomal gel with the help of soya lecithin, ethanol, poloxamer 407, and HPMC K100M utilizing the thin film hydration technique. The optimized formulation (F12) was completely characterized in terms of polydispersity index, vesicle size (nm), and entrapment efficiency (%). In vitro drug release at 24 h, stability study, and ex-vivo skin permeation pharmacodynamic studies were all evaluated. Results: The ethosomal formulations were optimized using 32 Central Composite Design (CCD) about the observed responses, which comprised vesicle size, entrapment efficiency, and percent drug release after 24 h, all included in this study. The optimal size range and zeta potential for the F12 formulation were determined to be 110.23 nm and -35.69, respectively. The generated drug-loaded ethosomal gel was spherical with a consistent size distribution and particle size. Morphological studies showed that Scanning Electron Microscope (SEM) was utilized to better study spherical multilamellar vesicles. The optimized ethosomal gel of zolmitriptan was determined to meet the stability criterion, as the Critical Quality Attributes (CQAs) did not vary significantly during the study period. Conclusion: For all formulations, the F12 batch showed vesicle size (110.23 nm), entrapment efficiency (82.02%), and drug release percentage of 89.26% at 24 h.

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Formulation and Characterization of Intranasal Drug Delivery of Frovatriptan-Loaded Binary Ethosomes Gel for Brain Targeting

Cited by 5 publications

References 62 publications

Development and Optimization of Dipyridamole- and Roflumilast-Loaded Nanoemulsion and Nanoemulgel for Enhanced Skin Permeation: Formulation, Characterization, and In Vitro Assessment

Development and Optimization of Dipyridamole- and Roflumilast-Loaded Nanoemulsion and Nanoemulgel for Enhanced Skin Permeation: Formulation, Characterization, and In Vitro Assessment

Ethosomes: a potential nanovesicular carrier to enhancing the drug delivery against skin barriers

Quality by Design Enables Formulation Development of Zolmitriptan Loaded Ethosomal Intra-Nasal Gel for Brain Targeting: In Vitro and Ex Vivo Evaluation

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