Formulation and characterization of floating microballoons of Nizatidine for effective treatment of gastric ulcers in murine model

Jain, Akash; Pandey, Vikas; Ganeshpurkar, Aditya; Dubey, Nazneen; Bansal, Divya

doi:10.3109/10717544.2014.891273

Cited by 21 publications

(17 citation statements)

References 20 publications

(16 reference statements)

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“…Where Wf and Ws are the weights of the floating and settled microspheres 5. Scanning Electron Microscopy: 8 Dry hollow microspheres are placed on an electron microscope brass stub a coated with gold in an ion sputter. Then pictures of microsphere are taken by Spectro random scanning of the stub.…”

Section: Buoyancy (%) = {Wf / (Wf + Ws)} × 100mentioning

confidence: 99%

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2020

IJPSR

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Hollow microballoons (microspheres) are spherical empty particles without core. Microballoons (Hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug-delivery systems are based on a noneffervescent system containing empty particles of spherical shape without core ideally having a size less than 200 micrometers. Microballoons drug delivery systems have shown to be of better significance in controlling the release rate for drugs having site-specific absorption. The floating microballoons showed gastro retentive controlled release delivery with efficient means of enhancing the bioavailability and promises to be a potential approach for gastric retention. Optimized hollow microspheres will find the central place in novel drug delivery, particularly in safe, targeted and effective in-vivo delivery promises to be a potential approach for gastric retention. They are gastro retentive drug-delivery systems, which provide controlled release properties. The advantages, limitations, methods of preparation of hollow microsphere, applications, polymers used in hollow microspheres, characterizations of microballoons and formulation aspects with various evaluation techniques and marketed products are covered in detail.

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Section: Buoyancy (%) = {Wf / (Wf + Ws)} × 100mentioning

confidence: 99%

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2020

IJPSR

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“…The position of ASP-MPs in the rat's stomach was monitored by X-ray photographs (Siregraph-B, Siemens, Germany) of the gastric region at varying time intervals upto 10 h (Figure no.7). 28 .…”

Section: Determination Of Percent Drug Loading and Drug Entrapment Efmentioning

confidence: 99%

Preparation of Sterculia foetida - pullulan based semi-interpenetrating polymer network gastroretentive microspheres of amoxicillin trihydrate and optimization by response surface methodology

Khan¹,

Hadke²

2020

tjps

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INTRODUCTION: In the current investigation a novel sterculia foetida and pullulan based semiinterpenetrating polymer network gastroretentive microsphere formulation was prepared by emulsion crosslinking method and optimized by central composite design. METHODS: The effect of amount of glutraldehyde, sterculia foetida and pullulan on percent drug entrapment efficiency (% EE), percent mucoadhesion at 12h and percent in vitro drug release at 12h (% Q12h) were optimized. The microspheres were also characterized by SEM, FTIR and DSC. RESULTS: The formulation containing 4%v/v Glutraldehyde, 8.28%w/v pullulan and 2.14% w/v sterculia foetida had 88.75± 1.18% EF, gave 80.43± 1.2% drug release in 12 h and 81.73± 1.50% mucoadhesion at 12 h was considered optimum and was used for in-vivo radiographic study. DISCUSSION AND CONCLUSION: From the study it was concluded that semiinterpenetrating polymer network microspheres loaded with amoxicillin trihydrate were successfully prepared using Sterculia foetida and pullulan gum. The prolong retention of microspheres in the stomach with sustained drug release could effectively act against the H-Pyroli reservoir in the stomach and improve the therapeutic effectiveness of amoxicillin trihydrate against H-Pyroli.

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“…The hallow microspheres were developed by double emulsion solvent evaporation diffusion technique using ethyl cellulose, hydroxyl propyl methyl cellulose, and eudragit E 100 as polymers which provide better encapsulation efficiency 10,11,12 . Ethyl cellulose was used as a retarding polymer where as HPMC and eudragit E 100 dissolves at gastric pH 13 .…”

Section: Quick Response Codementioning

confidence: 99%

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2018

IJPSR

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The purpose of present study was to formulate the gastroretentive floating microspheres of atazanavir sulfate to be retentive in the stomach for prolonged period of time. The gastro-retentive floating microspheres were prepared by double emulsion w 1 /o/w 2 solvent evaporation technique and characterization for particle size, SEM, floating time, FTIR, DSC, and entrapment efficiency. The in-vitro drug release studies and invitro drug kinetics were performed for different formulations. FTIR and DSC studies revealed that the drug is compatible with excipients. The floating time of the floating microspheres was found to be > 12h. The particle size of all the formulations was evaluated by optical microscopy method. Formulation F1-F4 comprising HPMC as rate retarding polymer exhibits an average particle size of about 515.25µm and microspheres F5-F8 prepared with eudragit exhibit a mean particle of about 611.4 µm. Eudragit formulations exhibit an increased entrapment efficiency which is due to its large particle size and increased viscosity. All batches prepared show an initial burst release followed by sustained release. Formulation F 1 to F4 exhibits an in vitro release of 67.8%, 70.9%, 77.8% and 87% respectively at the end of 10 th h. Formulation F5 to F8 exhibits a release of 36.1%, 54.6%, 57.6% and 67.8% respectively at the end of 10 th h. Among all the formulations, F4 prepared with combination of HPMC and ethyl cellulose exhibits sustained release behavior. The developed floating microspheres assure the delivery of drug for a prolonged period of time.

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Formulation and characterization of floating microballoons of Nizatidine for effective treatment of gastric ulcers in murine model

Cited by 21 publications

References 20 publications

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Preparation of Sterculia foetida - pullulan based semi-interpenetrating polymer network gastroretentive microspheres of amoxicillin trihydrate and optimization by response surface methodology

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