Formulation and Characterization of Electrospun Nanofibers Loaded Fusidic Acid for Wound Dressing Technique

Abstract

Electrospinning technology has been introduced as a new drug delivery system particularly when used for topical administration which shows excellent results in the treatment of various skin diseases. The combination of synthetic polymer (Polyvinyl alcohol) with biocompatible and biodegradable polymer (Chitosan) in a specific ratio to carry antibacterial agent (Fusidic acid) in the form of electrospun nanofibers to be used in wound dressing to treat different types of infections and ulcerations of the skin. The prepared electrospun nanofibers solution is tested for viscosity to assist in selection of suitable ratio of (PVA/CS) to load the antibacterial agent and produce nanofibers loaded fusidic acid. The evaluation of nanofibers is performed by studying the morphology of nanofibers, loading efficiency, swelling test, ex-vivo which carried by using Franz diffusion cell and in-vivo drug release profile by testing the nanofibers on rat to determine the percent of wound contraction and compare the average cumulative drug release with conventional dosage form to understand the bust mechanism from the surface of nanofibers and controlled drug release from the formula.