Formulation and Biopharmaceutical Evaluation of Sustained Release Pellets of Bosentan by Pancoating Method
GVRAMI REDDY,
PALLAVI V.,
RAKESH P.
et al.
Abstract:Objective: The aim of the present study was to formulate sustained-release pellets of bosentan by eudragit RL 100 and RS 100, which are the polymers used in the pan coating technique.
Methods: The sustained release pellets of bosentan were formulated by pan coating method. The drug was coated on nonpareil seeds along with EudragitRL100 by solution layering technique. Drug-loaded pellets were coated with EudragitRS100. The prepared pellets were evaluated for moisture content, drug content, particle size, and in… Show more
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