Formulation and Assessment of the Efficacy and Stability of an Ointment Containing Ocimum americanum L. Extract

Akombaetwa, Nakamwi; Muungo, L; Nyirenda, James; Muwowo, Sergio; Kalungia, Aubrey; Mukosha, Moses; Mwila, Chiluba

doi:10.1016/j.ccmp.2022.100078

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Each experiment was carried out thrice. [14][15][16] Formulation and optimization The ointment comprising 5% concentration of extract with an essential oil blend, beeswax, and soft paraffin was made using the fusion process. A crucible containing weighed amounts of beeswax was filled with melted extract and stirred to ensure uniform mixing.…”

Section: (1)mentioning

confidence: 99%

Formulation of Herbal Topical Dermatological Dosage Form by Quality by Design Approach

Tiple,

Jamane,

Khobragade

et al. 2023

IJDDT

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Objective: The study developed an optimized dosage form by quality by design (QbD) approach containing Azadirachta indica (Neem) leaf extract and a combination of selected herbal oils viz. A. indica oil, Eucalyptus citriodora oil and Cymbopogon martini oil and assessed for its antifungal efficacy, stability and dermal safety. Methods: Ointment was prepared using the fusion method from an extract of neem leaves with a combination of herbal oils viz. A. indica, E. citriodora, C. martini, bees wax and soft-paraffin. Utilizing the Box-Behnken Design (BBD), the variables such as the percentage of soft paraffin, beeswax and melting temperature were optimized in relation to the output variables such as viscosity, spreadability, and finally the antifungal efficacy, which was further quantified. Wistar albino rats were used (n = 5/test, positive and negative control) to evaluate the acute dermal toxicity test of the formulated ointment. Stability studies were assessed at 25 ± 2℃/ 60 ± 5% RH and 40 ± 2℃/ 75 ± 5% RH. Results: Melting point and percentage of beeswax significantly affect viscosity and spreadability. Optimal viscosity was obtained at 5.4% beeswax and 89.6% soft-paraffin when melted at 58℃. No dermal toxicity was observed by the ointment when comparable to petroleum jelly, both differed significantly with negative control. The absence of new spots on chromatograms, a prominent zone on agar plates, and negligible changes in spreadability (p = 0.112) all suggested physical stability, chemical stability, and antifungal efficacy, respectively. Conclusion: Neem leaf extract and a blend of selected herbal oils; A. indica, E. citrodora, and C. martini, when combined to formulate ointment, proved reliable and stable dosage form with significant anti-fungal efficacy. The formulated ointment might be helpful tool for dermatophytes management.

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Section: (1)mentioning

confidence: 99%

Formulation of Herbal Topical Dermatological Dosage Form by Quality by Design Approach

Tiple,

Jamane,

Khobragade

et al. 2023

IJDDT

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“…Alternatives for the administration of the natural active compound have been explored, such as gels [29][30][31][32], ointments [33][34][35], and mainly orally disintegrating films [1,5,36]. Generally, oral films are developed from natural polymers [1,3,[36][37][38][39], and their characteristics, such as disintegration time, stability of the active compounds, and biological activities, among others, are determined since they can be affected by several factors.…”

Section: Introductionmentioning

confidence: 99%

Oral Films Printed with Green Propolis Ethanolic Extract

Remedio,

Garcia,

Rochetti

et al. 2024

Polymers

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Oral film (OF) research has intensified due to the effortless administration and advantages related to absorption in systemic circulation. Chitosan is one of the polymers widely used in the production of OFs; however, studies evaluating the maintenance of the active principles’ activity are incipient. Propolis has been widely used as an active compound due to its different actions. Printing techniques to incorporate propolis in OFs prove to be efficient. The objective of the present study is to develop and characterize oral films based on chitosan and propolis using printing techniques and to evaluate the main activities of the extract incorporated into the polymeric matrix. The OFs were characterized in relation to the structure using scanning and atomic force electron microscopy; the mechanical properties, disintegration time, wettability, and stability of antioxidant activity were evaluated. The ethanolic extract of green propolis (GPEE) concentration influenced the properties of the OFs. The stability (phenolic compounds and antioxidant activity) was reduced in the first 20 days, and after this period, it remained constant.

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Ocimum basilicum and Ocimum americanum: A Systematic Literature Review on Chemical Compositions and Antimicrobial Properties

Wirtu,

Mishra,

Jule

et al. 2024

Natural Product Communications

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Objectives This systematic review aimed to evaluate the chemical compositions and Pharmacological applications of Ocimum basilicum, known as sweet basil, and Ocimum americanum, known as hoary basil, to assess their antimicrobial properties. Both plants are renowned for their culinary uses and medicinal properties, with studies suggesting potential therapeutic benefits due to their rich essential oil. Methods A systematic approach was adopted to gather and analyze the relevant literature on the chemical profiles and pharmacological activities of Ocimum basilicum and Ocimum americanum. Electronic databases including Web of Science, ScienceDirect, Google Scholar, and PubMed were searched using keywords such as chemical composition of Ocimum basilicum, chemical composition of Ocimum americanum, antimicrobial activities of Ocimum basilicum, and antimicrobial activities of Ocimum americanum. Results Ninety-nine articles meeting the determined inclusion criteria were incorporated in this systematic review. Several studies have consistently demonstrated the antimicrobial activities of these 2 plants, although the specific compounds responsible for this activity vary between the 2 species. Conclusion The diverse array of bioactive molecules present in these plants contributes to their pharmacological effects, suggesting avenues for further research into their therapeutic applications. This review supports the continued exploration of the medicinal properties and potential development of sweet basil and hoary basil as antimicrobial agents.

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Formulation and Assessment of the Efficacy and Stability of an Ointment Containing Ocimum americanum L. Extract

Cited by 3 publications

References 13 publications

Formulation of Herbal Topical Dermatological Dosage Form by Quality by Design Approach

Formulation of Herbal Topical Dermatological Dosage Form by Quality by Design Approach

Oral Films Printed with Green Propolis Ethanolic Extract

Ocimum basilicum and Ocimum americanum: A Systematic Literature Review on Chemical Compositions and Antimicrobial Properties

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