Formulating blackberry leaf mixtures for preparation of infusions with plant derived sources of sweeteners

Komes, Draženka; Belščak‐Cvitanović, Ana; Ljubičić, Ivica; Durgo, Ksenija; Cindrić, Iva Juranović; Bušić, Arijana; Vojvodić, Aleksandra

doi:10.1016/j.foodchem.2013.11.087

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…These phytoconstituents express reductive activity on free radicals and may limit the appearance of mutations or even participate in DNA repair [24]. There are a few reports concerning the antitumour activity of other Rubus leaves extracts, but no data are available supporting the extracts from dewberry leaves [15, 16, 22, 25, 26]. Previous studies on in vitro models suggest that berry from Rubus species may influence colorectal cancer cell survival in concert terms proliferation and apoptosis [17].…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies on in vitro models suggest that berry from Rubus species may influence colorectal cancer cell survival in concert terms proliferation and apoptosis [17]. Komes and coworkers also revealed that infusion from R. fruticosus leaves may induce cytotoxic action against human colon cells, depending of time and concentration [26]. On the other hand, cancer development is closely associated with inflammation and mutatory microenvironments containing free radicals.…”

Section: Resultsmentioning

confidence: 99%

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In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation

Grochowski

Paduch

Wiater

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The present study was performed to evaluate the effect of different extracts and subfractions from Rubus caesius leaves on two human colon cancer cell lines obtained from two stages of the disease progression lines HT29 and SW948. Tested samples inhibited the viability of cells, both HT29 and SW948 lines, in a concentration-dependent manner. The most active was the ethyl acetate fraction which, applied at the highest concentration (250 μg/mL), decreased the viability of cells (HT29 and SW948) below 66%. The extracts and subfractions were also investigated for antioxidant activities on DPPH and FRAP assays. All extracts, with the exception of water extract at a dose of 250 μg/mL, almost totally reduced DPPH. The highest Fe3+ ion reduction was shown for the diethyl and ethyl acetate fractions. It was more than 6.5 times higher (at a dose 250 μg/mL) as compared to the control. The LC-MS studies of the analysed preparations showed that all samples contain a wide variety of polyphenolics, among which ellagitannins turned out to be the main constituents with dominant ellagic acid, sanguiin H-6, and flavonol derivatives.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation

Grochowski

Paduch

Wiater

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…It should be highlighted that fructose can display antioxidant properties due to its reducing capacity. Furthermore, sugars are one of the molecules present in plant infusions that contribute to their energetic value [ 21 ]. C. citratus gave the highest levels of glucose and sucrose ( Table 1 and Figure 1(b) ).…”

Section: Resultsmentioning

confidence: 99%

HPLC-Profiles of Tocopherols, Sugars, and Organic Acids in Three Medicinal Plants Consumed as Infusions

Roriz

Barros

Carvalho

et al. 2014

International Journal of Food Science

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Pterospartum tridentatum (L.) Willk, Gomphrena globosa L., and Cymbopogon citratus (DC.) Stapf are medicinal plants that require a more detailed chemical characterization, given the importance of their consumption as infusions. Therefore, the individual profiles in tocopherols, free sugars, and organic acids were obtained by high performance liquid chromatography (HPLC) coupled to different detectors (fluorescence, refraction index, and photodiode array, resp.). C. citratus revealed the highest content of α-, and total tocopherols, glucose, sucrose, succinic, and ascorbic acids. P. tridentatum presented the highest fructose and total sugars content. Otherwise, G. globosa showed the highest organic acids concentration. As far as we know, this is the first study reporting the mentioned chemical compounds in G. globosa and C. citratus.

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“…The trend of wide using and applications of herbs as herbal infusions or tea, as the common name, is preserved from traditional medicinal system to this day owing to the rich and diverse phytochemicals composition (Komes et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of extraction conditions on phenolic compounds from blackberry leaves extracts

Salević¹,

Kalušević²,

Lević³

et al. 2017

FoodBalt

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Blackberry leaves have been used as a tea substituent in many herbal mixtures. Medicinal properties of this plant material are related to a high level of components with antioxidant activity, such as phenolic compounds. The aim of the research was to evaluate the effect of different extraction conditions on the content of phenolic compounds and antioxidant activity of blackberry leaves extracts. In this study, blackberry leaves extracts were produced by an aqueous extraction procedure. Different extraction conditions: water temperature (40 and 80 °C) and extraction time (15 and 30 min) were investigated. The blackberry leaves extract prepared by applying higher temperature (80 °C) and longer time (30 minutes) was characterized by the highest contents of total phenolic compounds (1534.15 mg gallic acid equivalents L -1 ), flavonoids (715 mg quercetin equivalents L -1 ) and flavan-3-ols (28.21 mg (+)-catechin L -1 ). Also, this extract expressed the highest antioxidant activity in terms of the ferric reducing ability of plasma (27.33 mmol Trolox equivalents L -1 ) and generation of 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (1.47 mmol Trolox equivalents L -1 ). The obtained results indicated that the produced extracts are a rich source of phenolic compounds with high antioxidant activity. Among investigated conditions, the use of water heated to higher temperature (80 °C) during prolonged time (30 min) is the most optimal procedure for the extraction of phenolic compounds with antioxidant activity from blackberry leaves. Further research is needed to determine the exact phenolic profile and their bioavailability, as well as to develop new functional food ingredients or nutraceuticals containing blackberry leaves extracts.

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Formulating blackberry leaf mixtures for preparation of infusions with plant derived sources of sweeteners

Cited by 6 publications

References 32 publications

In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation

In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation

HPLC-Profiles of Tocopherols, Sugars, and Organic Acids in Three Medicinal Plants Consumed as Infusions

Effect of extraction conditions on phenolic compounds from blackberry leaves extracts

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