Formulasi Sediaan Gel dari Ekstrak Metanol Biji Alpukat (Persea americana Mill.) Sebagai Penyembuh Luka Sayat Pada Tikus Jantan (Rattus norvegicus)

Abstract

The avocado (Persea americana Mill.) is a fruit that is often found. This versatile fruit has many benefits for humans. The benefits of avocado are as anti-hyperlipidemic, analgesic, anti-inflammatory, anticonvulsant, hypoglycemic, hypercholesterolemic, wound healing and prevent cancer. The aims of this study was to make avocado seed methanol extract into a gel preparation and to determine the effect of avocado seed methanol extract gel and at what concentration the effective treatment for wounds in mice and its comparison with Star Ag gel as a positive control. The research was conducted using an experimental method. The manufacture of avocado seed methanol exstract was carried out by maceration method using methanol as a solvent. The result of the study were statistically analyzed using One Way Anova. The result of the data analysis at a concentration of 5% obtained a sig value <0,05. Based on One Way Anova analysis of the five treatments, the most effective was avocado seed methanol extract gel with a concentration of 5%.

FORMULASI SEDIAAN GEL EKSTRAK KULIT BATANG ASAM KANDIS (Garcinia xanthochymus Hook.f. ex. Anderson) DAN UJI ANTIINFLAMASI TERHADAP TIKUS PUTIH JANTAN

“…Kemudian elektroda dicuci dengan air suling, lalu dikeringkan atau di lap dengan kertas tisu.Sampel dibuat dalam konsentrasi 1% yaitu ditimbang 1 gram sediaan dan dilarutkan dalam 100 ml air suling, kemudian elektroda dicelupkan dalam larutan tersebut, sampai alat menunjukkan harga pH yang konstan. Angka yang ditunjukkan pH meter merupakan harga pH sediaan (Kaban et al, 2022).…”

Uji Aktivitas Penyembuhan Luka Sayat Gel Ekstrak Etanol Lidah Buaya (Aloe Vera L.) pada Mencit Putih Jantan (Mus Musculus)

“…Sediaan gel merupakan salah satu alternatif pengobatan topikal untuk penyembuhan luka, karena memberikan efek mendinginkan sebab kandungan airnya yang tinggi sehingga zat tersebut dapat menembus jaringan dengan lebih baik. Gel merupakan sediaan farmasi yang memiliki kelebihan tidak lengket dan mudah dibersihkan sehingga luka lebih cepat sembuh (Kaban et al, 2022).…”

Phytochemical Screening and Formulation of Hand Sanitizer Gel Preparations from Temu Hitam Rhizome Extract (Curcuma aeruginosa Roxb)

“…The formulation of the Temu Hitam rhizome hand sanitizer gel preparation can be seen in Where: F1: Formulation without the content of Temu Hitam rhizome extract F2: Formula with 5% temu hitam rhizome extract F3: Formula with 10% temu hitam rhizome extract F4: Formula with 15% temu hitam rhizome extract Formula was made in three formulations with varying concentrations of Carbomer 940 rhizome extract sprinkled on a mortar, added with hot water, and stirred rapidly in a mortar to avoid agglomerates until a gel mass was formed, then neutralized with the addition of TEA as a base [21]. Methyl paraben and propyl paraben were each dissolved in distilled water.…”

“…Organoleptic testing is a test carried out to see the shape, color, and smell of the preparation visually [21] Viscosity Test A Brookfield viscometer was used to determine the viscosity. The viscosity of the hand sanitizing gel will be determined by measuring 100 mL of the hand sanitizing gel preparation, the ethanol extract of the black ginger rhizome, then changing the spindle and the speed employed and running a viscometer [22].…”

“…The gel preparation was placed on a glass plate and then overwritten with another glass plate for 1 minute, then the diameter of the preparation formed was measured using a caliper [21] III.…”