Formulasi Sediaan Gel Dari Ekstrak Etanol Herba Pegagan (Centella asiatica (L) Urb)

Abstract

Indonesia is a rich country in terms of flora and fauna diversity. Indonesia's wealth with various types of flora is a highlight for science, one of which is the gotu kola herb (Centella asiatica (L) Urb). The chemical compound asiaticoside is part of the triperoids contained in the gotu kola herb which has the potential as antibacterial, antifungal, antioxidant and anti-cellulite on the skin, suitable for topical preparations such as gels. This study aims to formulate a gel preparation from the ethanolic extract of the gotu kola herb (Centella asiatica (L) Urb) which meets the requirements of a good gel. The formulation of the gel preparation was carried out with concentrations of 20%, 25%, and 30%. Extracted by maceration method using 70% ethanol and in a vacuum rotary evaporator to obtain a thick extract. Evaluation of the gel preparation was carried out by organoleptic test, homogeneity test, pH test, dispersibility test, adhesion test and irritation test. The results of the evaluation carried out with the three concentrations met the requirements of the organoleptic test, homogeneity test, pH test, adhesion test and irritation test, but the ethanol extract gel of the gotu kola herb at concentrations of 20%, 25% and 30% did not meet the requirements for the good dispersion test

Pembuatan Sediaan Gel Dari Ekstrak Herba Pegagan (Centella Asiatica L. Urban) Sebagai Obat Luka Sayat

“…Kemudian metil paraben dilarutkan dalam propilen glikol hingga tercampur lalu campuran tersebut dimasukkan ke dalam basis gel sedikit demi sedikit sambil terus diaduk, tambahkan ekstrak pegagan sesuai konsentrasi variabel dan diaduk hingga homogen. Tambahkan aquadest hingga sediaan gel mencapai 100 gram sambil terus diaduk dan dikemas dalam tube yang tertutup rapat (Rahimah et al, 2021) (Nurlatifah et al, 2022). Uji Daya Lekat Ditimbang gel 0,5 g diletakkan dikaca objek, dan ditutup.…”

“…Beban kemudian diangkat dan kaca objek dipasang pada alat uji daya lekat. Alat uji diberi beban 8 g. Catat waktu pelepasan kaca objek tersebut (Nurlatifah et al, 2022).…”

“…Semakin tinggi daya sebar menunjukkan bahwa kemampuan menyebarnya zat aktif dan kontak dengan kulit semakin luas. Hasil uji daya sebar memenuhi syarat sediaan gel yang baik yaitu 5-7 cm (Nurlatifah et al, 2022).…”

“…Semakin tinggi daya lekat gel maka absorpsi obat akan tinggi terhadap kulit, dikarenakan kuatnya ikatan antara gel dengan kulit. Hasil uji daya lekat memenuhi syarat sediaan gel yang baik yaitu 2-300 detik (Nurlatifah et al, 2022).…”