Formulasi dan Uji Aktivitas Gel Anti Jerawat Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi Linn)

Abstract

Averrhoa bilimbi Linn is a plant that is used by the local community as an itchy and acne remedy. Secondary metabolite content of ethanol extract of Starfruit leaves (Averrhoa bilimbi Linn) can inhibit the growth of acne bacteria. The purpose of this study was to determine the best concentration in the manufacture of anti-acne gel formulations of ethanol extract of Starfruit leaves (Averrhoa bilimbi Linn) using HPMC base. Extract concentrations were made of 5%, 7.5%, and 10%. After antibacterial tests, the extract concentration used was 7.5% with a inhibition zone of 11.17 mm P.acnes bacteria and 11.30 mm S.aureus bacteria. Anti-acne gel ethanol extract of starfruit leaves (Averrhoa bilimbi Linn) made 3 replication formulas with extract levels FR1 (7.5%), FR2 (7.5%) and FR3 (7.5%). The results showed that the color of the dark green preparation, distinctive smell, thick, no syneresis, ph 4.7-6.2, scatter power 4.6-5.2 cm, clinginess 6-22 seconds and viscosity of 11-20 Pa.s. Antibacterial activity tests on P.acnes showed a inhibition zone of 10.1-10.73 mm and S.aureus showed a inhibition zone of 10.35-10.93 mm. So, it was concluded that the formulation of anti-acne gel was able to inhibit the growth of P.acnes and S.aureus bacteria and meet physical characteristics.

Effect of Hydroxypropyl Methylcellulose (Hpmc) as Gelling Agent on Physical Characteristics and Antibacterial Potential of Tamoenju Leaves Extract Gel (Hibiscus Surattensis L) Against Staphylococcus Aureus

“…Gel preparations underwent an adhesiveness test to ascertain the amount of time needed for the gel to stick to the skin, as it significantly affects the effectiveness of the preparations in delivering therapeutic effects. The required adhesion time is more than 4 seconds [16]. After 36 d of storage, the adhesion of all gel formulations decreased.…”

Antibacterial Activity Test of Anti-Acne Gel Preparations Containing Ethanol Extracts of Bidara Arab Leaf (Ziziphus spina-christi (L.) Desf) Againts Propionibacterium acnes

“…Gel preparations are better used for acne treatment because gel with polar solvents is easier to clean from the surface of the facial skin after use and do not contain oil which can increase the severity of acne. The benefits of topical gel preparations include increased activity and usability, the ability to deliver active substance or medicinal ingredients properly 5 .…”

“…Give each one the amount needed. Then, steadily grind until homogeneous till an anti-acne gel preparation was made from the bidara arab leaves 5 .…”

“…Furthermore, the electrode is immersed in the gel base until the tool demonstrates a consistent pH. Human facial skin has a pH that ranges from 4.5 to 6.5 5 . Copyright© 2023 Muzayyidah, Page 24…”

Penyuluhan Pembuatan Sediaan Masker Peel Off Kombinasi Ekstrak Daun Sirih Hijau dan Buah Belimbing Wuluh di Desa Bendiljati Wetan

“…Saat ini, penggunaan kosmetik berbahan dasar alami dari tanaman mulai banyak dikembangkan agar tercipta kosmetik yang aman bagi kulit, salah satunya dengan bahan aktif daun sirih hijau (Piper betle L.) dan buah belimbing wuluh (Averrhoa bilimbi L.). Pada beberapa literatur melaporkan manfaat dari kandungan flavonoid pada daun sirih hijau dan buah belimbing wuluh, salah satunya sebagai obat jerawat (Ikhsanudin & Mardhiyah, 2017).…”