FORMULASI DAN EVALUASI FISIK SEDIAAN KAPSUL EKSTRAK DAUN CINCAU HIJAU (Cyclea barbata Miers ) SEBAGAI ANTI INFLAMASI

Wulandari, Fitria; Widyawati, Fitri; Rizaldi, Khusnul; Syaputri, Fauzia Ningrum

doi:10.33096/jifa.v12i2.638

Cited by 2 publications

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“…This recent study showed that pumpkin seed flour has a density of 0.2427 g/ml which means fulfilling the requirement for incompressible density >0.21 g/ml. 20 The flow time test was carried out to determine the time required for pumpkin seed flour to flow through the test equipment. To our best knowledge, it is the first study to examine flour flow from the seeds.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Quality of Pumpkin Seed Flour and Capsules as Food Supplements

Syam

2022

MKMI

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Pumpkin seeds contain a variety of useful nutrients, so they become a food supplement. This study aimed to evaluate the quality of pumpkin seed flour and capsules. This study used the experimental method. The pumpkin used came from a local market in Makassar City. Cleaned pumpkin seeds-then dried in the sun for ± 7 hours. After that, put them in the oven at a temperature of 70-75°C for 3 hours. Next, blended them until they became smooth flour and sieved through a 70 mesh sieve. Put the flour into a capsule shell size 00. The quality of pumpkin seed flour and capsules is tested at the Neutraseutical Laboratory and the Integrated Laboratory of Hasanuddin University. The evaluation of flour quality was carried out with 3 indicators which are the moisture content test, the incompressible density test, and the flow time test. Meanwhile, the evaluation of capsule quality was also carried out with 3 indicators, which are the time disintegration test, the weight diversity test, and the shelf-life test. Based on the evaluation of flour quality, pumpkin seed flour meet the required standards for the moisture content test (3.57%) and the incompressible density test (0.2427 g/cm3), but did not meet the required standards for the flow time test. Furthermore, pumpkin seed capsules meet the required standards for the three indicators tested, namely, the weight diversity (according to Pharmacopeia 1 edition 3), the time disintegration (6 minutes) and the shelf-life (115 days). Pumpkin seed flour and capsules can be used as food supplements because they meet the required standards to evaluate quality.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Quality of Pumpkin Seed Flour and Capsules as Food Supplements

Syam

2022

MKMI

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“…Meanwhile, a dose of 200 mg, 400 mg and Na-CMC are in different columns, indicating that the diarrhea value in each treatment was significantly different from the positive control group. 13 Furthermore, in the statistical test results in the column, the results of the frequency of diarrhea at a dose of 400 mg, a dose of 800 mg, Loperamide, a dose of 200 mg and Na-CMC were in the same column, concluding that the value of diarrhea in each of these treatments was not significantly different. The results of the loperamide stool weight at a dose of 800 mg, 200 mg, 400 mg and Na-CMC were in the same column, concluding that the value of diarrhea in each of these treatments was not significantly different.…”

Section: Alkaloidsmentioning

confidence: 92%

Comparison Between The Suspension and Capsule Preparation from Waste of Avocado Seeds As Antidiarrhea in Induced Mouse

Saputri¹,

Zebua²,

Asih³

et al. 2022

JFAPS

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Diarrhea is one type of disease with the most sufferers every year. Thus, it is considered an endemic disease in Indonesia and the potential disease of Extraordinary Events accompanied by mortality. One of the plants that can be used as a traditional medicine for diarrhea is the avocado seed, as it contains tannins, alkaloids, flavonoids, steroids and glycosides, which act as antidiarrheals. This study aims to determine the antidiarrheal effect of avocado seed extract suspension on mice induced by Oleum ricini and the optimum concentration of avocado seed extract suspension and capsules with an antidiarrheal effect in white male mice induced by Oleum ricini. The dosage forms chosen were suspension and capsules. This study used an experimental method with a test sample of the avocado seed. Avocado seed Simplicia was extracted by the percolation method, then an oral suspension and capsule formulation were made from the avocado seed methanol extract. It was evaluated and tested for its effectiveness with mice to cure diarrhea. Normal data were analyzed by One Way ANOVA and Post Hoc Tuckey Method. The results of this study showed that the administration of a suspension of avocado seed methanol extract at a dose of 800 mg/KgBB had the most optimum effect as an antidiarrheal against white male mice with a stool weight of 0.39 grams and a duration of diarrhea for 74 minutes. Furthermore, the administration of avocado seed extract capsules at a dose of 75 mg/KgBB had the most optimum effect as antidiarrheal against white male mice with Loperamide as a positive control. Therefore, it can be concluded that all suspension formulations and capsules of avocado seed methanol extract met the requirements for preparation evaluation. Suspension and avocado seed methanol extract capsules can cure diarrhea in white male mice.

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FORMULASI DAN EVALUASI FISIK SEDIAAN KAPSUL EKSTRAK DAUN CINCAU HIJAU (Cyclea barbata Miers ) SEBAGAI ANTI INFLAMASI

Cited by 2 publications

References 0 publications

Evaluation of the Quality of Pumpkin Seed Flour and Capsules as Food Supplements

Evaluation of the Quality of Pumpkin Seed Flour and Capsules as Food Supplements

Comparison Between The Suspension and Capsule Preparation from Waste of Avocado Seeds As Antidiarrhea in Induced Mouse

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