Formula-Driven, Size-Tunable Synthesis of PMMA Nanoparticles by Varying Surfactant Concentration

Kamras, Brian Leon; Mirzanasiri, Nooshin; Korir, Daniel K.; Mandal, Sujata; Hariharakumar, Shreya L.; Petros, Robby A.; Marpu, Sreekar B.; Simmons, Denise Perry; Omary, Mohammad A.

doi:10.3390/ma13081834

Cited by 2 publications

(6 citation statements)

References 29 publications

(31 reference statements)

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“…Table 2 shows the parameters of the fitted function to relate the change in PMMA sphere diameter as a function of SDS surfactant concentration. The results of this investigation are similar to those found by other authors on the change of PMMA sphere size as a function of SDS surfactant concentration, in which they report a nonlinear behavior, although with a second-order exponential decay function [28]. Although surfactant concentration was similar, the particle size intervals show considerable differences in nanoparticle sizes (20-97 nm) relative to this work.…”

Section: Fit a Functionsupporting

confidence: 90%

“…The equation modeling the diameter size of PMMA spheres as a function of % SDS is valid between 120 to 360 nm. Kamras et al reported the validity of a second-order exponential decay equation between 20 and 97 nm [28]. Other works reported a relationship with particle size between 300 and 1000 [28,44].…”

Section: Fit a Functionmentioning

confidence: 96%

“…Vargas-Salazar et al synthesized PMMA by ultrasound at 50 • C with Hitenol BC10 as a surfactant and reported average particle diameters between 39 and 63 nm [27]. However, the most frequently used surfactant for PMMA synthesis is sodium dodecyl sulfate (SDS), for which some reports have found particle diameters between 20 and 97 nm [28] and between 100 and 1000 nm [29].…”

Section: Introductionmentioning

confidence: 99%

“…Kamras et al prepared PMMA by emulsion polymerization using microwave radiation as a heating source. They measured the Zaverage particle size using the dynamic light scattering (DLS) technique, reporting particle sizes between 97.36 and 23.19 nm using 0.008 and 0.2 % SDS [28]. There has been no report about PMMA sphere synthesis by emulsion polymerization and conventional heating as a function of the variation of the amount of SDS as surfactant.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis of PMMA Microspheres with Tunable Diameters: Evaluation as a Template in the Synthesis of Tin Oxide Coatings

Mendoza-Castellanos,

Pantoja-Espinoza,

Rodríguez-Pacheco

et al. 2023

Polymers

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The synthesis of polymethyl methacrylate (PMMA) spheres with different sizes has been a challenge. PMMA has promise for future applications, e.g., as a template for preparing porous oxide coatings by thermal decomposition. Different amounts of SDS as a surfactant are used as an alternative to control PMMA microsphere size through the formation of micelles. The objectives of the study were twofold: firstly, to determine the mathematical relationship between SDS concentration and PMMA sphere diameter, and secondly, to assess the efficacy of PMMA spheres as templates for SnO2 coating synthesis and their impact on porosity. The study used FTIR, TGA, and SEM techniques to analyze the PMMA samples, and SEM and TEM techniques were used for SnO2 coatings. The results showed that PMMA sphere diameter could be adjusted by varying the SDS concentration, with sizes ranging from 120 to 360 nm. The mathematical relationship between PMMA sphere diameter and SDS concentration was determined with a y = axb type equation. The porosity of SnO2 coatings was found to be dependent on the PMMA sphere diameter used as a template. The research concludes that PMMA can be used as a template to produce oxide coatings, such as SnO2, with tunable porosities.

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Section: Fit a Functionsupporting

confidence: 90%

Section: Fit a Functionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of PMMA Microspheres with Tunable Diameters: Evaluation as a Template in the Synthesis of Tin Oxide Coatings

Mendoza-Castellanos,

Pantoja-Espinoza,

Rodríguez-Pacheco

et al. 2023

Polymers

View full text Add to dashboard Cite

show abstract

“…Moreover, the inherent agent re-design possibilities for He-Ne laser and AgPP NP can influence improved treatment outcomes. In this regard, we have expertise in metallic polymeric NP size tunability [32], Ag-PMMA cargo delivery with PAA synthesis stability for longer circulating times [29], and the use of light to treat central nervous system heterogeneic brain disorders [33].…”

Section: Inherent Challenges To Expected Outcomesmentioning

confidence: 99%

Empirical Studies on Effect of Low-Level Laser Treatment on Glioblastoma Multiforme in Combination with Ag-PMMA-PAA Nanoparticles: Paired Red Region Optical-Property Treatment Platform

et al. 2022

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Glioblastoma multiforme is an aggressive, invasive, fatal primary heterogenic brain tumor. New treatments have not significantly improved the dismal survival rate. Low-level laser therapy reports indicate different tumor cells respond distinctly to low-level laser therapy based on laser dose (J/cm2) or with nanotherapeutics. We investigated the effects of pairing two optical property-driven treatment agents—a low-level laser on glioblastoma multiforme (U251) using an He-Ne laser (632.8 nm) with 18.8 nm spherical Ag-PMMA-PAA nanoparticles, with an absorbance peak at 400 nm with a broad shoulder to 700 nm. The He-Ne treatment parameters were power (14.87 ± 0.3 mW), beam diameter (0.68 cm), and exposure time 5 min leading to a 12.28 J/cm2 dose. A dose of 12.28 J/cm2 was applied to Ag-PMMA-PAA nanoparticle concentrations (110–225 μM). An amount of 110 μM Ag-PMMA-PAA nanoparticles combined with an He-Ne dose at 18 h yielded 23% U251 death compared to He-Ne alone which yielded 8% U251 death. A 225 μM Ag-PMMA-PAA nanoparticle He-Ne combination resulted in an earlier, more significant, U251 death of 38% at 6 h compared to 30% with 225 μM alone at 18 h. Both treatment agents possess inherent physical and functional properties capable of redesign to enhance the observed cell death effects. Our results provide evidence supporting next-step studies to test “the redesign hypothesis” that these paired optical-driven agents provide a tunable platform that can generate significant U251 cell death increase.

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Formula-Driven, Size-Tunable Synthesis of PMMA Nanoparticles by Varying Surfactant Concentration

Cited by 2 publications

References 29 publications

Synthesis of PMMA Microspheres with Tunable Diameters: Evaluation as a Template in the Synthesis of Tin Oxide Coatings

Synthesis of PMMA Microspheres with Tunable Diameters: Evaluation as a Template in the Synthesis of Tin Oxide Coatings

Empirical Studies on Effect of Low-Level Laser Treatment on Glioblastoma Multiforme in Combination with Ag-PMMA-PAA Nanoparticles: Paired Red Region Optical-Property Treatment Platform

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