Formononetin ameliorates mast cell‑mediated allergic inflammation via inhibition of histamine release and production of pro‑inflammatory cytokines

Xu, Ning; An, Jun

doi:10.3892/etm.2017.5293

Cited by 22 publications

(19 citation statements)

References 25 publications

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“…Moreover, elaeocarpusin from Elaeocarpus sylvestris significantly decreased TNF‐α and IL‐4 production via suppression of NF‐κB activation in mast cells (Kim et al, ). Besides, the suppressive effect of formononetin on NF‐κB activation also contributed to the attenuation of IL‐1β, IL‐6, and TNF‐α production (Xu & An, ). Hence, the suppressive effect of myricetin on IL‐4 and TNF‐α production was suggested due to inactivation of NF‐κB.…”

Section: Resultsmentioning

confidence: 99%

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Kim

et al. 2020

J Food Biochem

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Rhodomyrtus tomentosa was reported to contain various bioactive metabolites, especially phenolic compounds. In the present study, the suppressive activity of phenolic compound from R. tomentosa fruits on mast cell activation was investigated in vitro. The result showed that myricetin was isolated from R. tomentosa fruits and its characterization was identified by nuclear magnetic resonance spectroscopy. Notably, myricetin was found to be effective in inhibition of mast cell degranulation by attenuating the release of β‐hexosaminidase and the elevation of intracellular calcium. Moreover, myricetin exhibited inhibitory effect on the production of IL‐4 and Tumor necrosis factor alpha (TNF‐α) in a concentration‐dependent manner. Furthermore, high antioxidant activity of myricetin due to scavenging 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) and ABTS+ radicals was also evidenced. Notably, the activation of FcɛRI‐mediated signaling molecules including Syk, PLCγ, and NF‐κB was also suppressed by myricetin treatment. Accordingly, myricetin from R. tomentosa fruits could be suggested as a functional food for the amelioration of allergic diseases. Practical applications Polyphenol have been shown to exert various biological activities and health beneficial effects. Results from the present study revealed that myricetin from R. tomentosa fruits possesses the inhibitory effect on allergic response in mast cells. Therefore, myricetin from R. tomentosa fruits could be developed as a functional ingredient for the amelioration of allergic diseases.

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Section: Resultsmentioning

confidence: 99%

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Kim

et al. 2020

J Food Biochem

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“…For example, an interesting study reported the effectiveness of lupeol for treating or reducing inflammation in a rat arthritis model (Geetha and Varalakshmi 2001). Formonetine in cell cultures has demonstrated potent anti-inflammatory properties, due to its ability to reduce the release of histamine (Xu and An 2017). In addition, anti-inflammatory and antinociceptive effects are reported for isoliquirititigenin and liquirititigenin (Kim et al.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea

Cruz

Díaz

Gupta

et al. 2019

Pharmaceutical Biology

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Context: Since there is still a great need to search for plant species with antinociceptive and anti-inflammatory activities, Diploptropis purpurea (Rich.) Amshoff (Fabaceae) is studied for the first time. Objective: This evaluates the analgesic and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea (MEDP). Material and methods: The anti-inflammatory and analgesic effects of MEDP of D. purpurea were evaluated in vivo . The antinociceptive activity was assessed in CD1 male mice were treated by oral gavage with 500 mg/kg of MEDP 30 min before submitting to acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Paws oedema induced by carrageenan, histamine or serotonin were performed in male Sprague–Dawley rats to determinate the anti-inflammatory activity. Results: Oral administration of MEDP produced significant antinociceptive effects on the inflammatory phase in the formalin test [12.0 s versus 72.5 s in carboxymethyl cellulose (CMC) control group]. MEDP produced an analgesic effect in the hot-plate model, although the effect was modest compared to tramadol (40 and 60%, respectively). The oral administration of MEDP in a dose of 500 mg/kg showed maximum inhibition (75.1%) after 0.5 h in carrageenan-induced oedema, but it did not modify histamine or serotonin-induced oedemas. Discussion and conclusion: In the peripheral nociception model, acetic acid-induced abdominal writhing, the MEDP did not show a protective effect, but its analgesic effects were evident in the inflammatory phase of the formalin test and in the hot-plate model. These results show that the anti-inflammatory effect was accompanied by a reduction in the perception of painful stimuli.

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“…FMT has a bioavailability of 21.8% and shows different absorption in all gastrointestinal segments ( Luo et al., 2018 ). An increasing body of evidence suggests that FMT exerts notable anti-inflammatory, anti-allergic, antioxidant, anti-hepatic steatosis, antiproliferative, and anticancer effects in vitro and animal models of many disease ( Wang et al., 2012 ; Xu and An, 2017 ; Fei et al., 2018 ; Li et al., 2018 ; Ong et al., 2019 ; Wang X. S. et al., 2019 ). Some reports demonstrate that FMT has neuroprotective effect in LPS-stimulated BV2 microglia and high-fat diet-induced cognitive disorder mice ( El-Bakoush and Olajide, 2018 ; Fu et al., 2019 ; Wang Y. et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Formononetin Attenuates Airway Inﬂammation and Oxidative Stress in Murine Allergic Asthma

et al. 2020

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Allergic asthma has been considered as a respiratory disorder with pathological features of airway inflammation and remodeling, which involves oxidative stress. Formononetin (FMT) is a bioactive isoflavone obtained from Chinese herb Radix Astragali, and has been reported to have notable anti-inflammatory and antioxidant effects in several diseases. The purpose of our study was to elaborate the effects of FMT on asthma and the underlying mechanisms. To establish allergic asthma model, BALB/c mice were given ovalbumin (OVA) sensitization and challenge, treated with FMT (10, 20, 40 mg/kg) or dexamethasone (2 mg/kg). The effects of FMT on lung inflammation and oxidative stress were assessed. In OVA-induced asthmatic mice, FMT treatments significantly ameliorated lung function, alleviated lung inflammation including infiltration of inflammatory cells, the elevated levels of interleukin (IL)-4, IL-5, and IL-13, immunoglobulin (Ig) E, CC motif chemokine ligand 5 (CCL5, also known as RANTES), CCL11 (also called Eotaxin-1), and IL-17A. In addition, FMT treatments eminently blunted goblet cell hyperplasia and collagen deposition, and remarkably reduced oxidative stress as displayed by decreased reactive oxygen species (ROS), and increased superoxide diamutase (SOD) activity. Furthermore, to clarify the potential mechanisms responsible for the effects, we determined the inflammation and oxidation-related signaling pathway including nuclear factor kappa b (NF-kB), c-Jun N-terminal kinase (JNK), and the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). FMT treatments appeared to dramatically inhibit the activation of NF-kB and JNK, significantly elevated the expression of heme oxygenase 1 (HO-1) but failed to activate expression of Nrf2. In conclusion, our study suggested that FMT had the therapeutic effects in attenuating airway inflammation and oxidative stress in asthma.

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Formononetin ameliorates mast cell‑mediated allergic inflammation via inhibition of histamine release and production of pro‑inflammatory cytokines

Cited by 22 publications

References 25 publications

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea

Formononetin Attenuates Airway Inﬂammation and Oxidative Stress in Murine Allergic Asthma

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