Forming Sticky Droplets from Slippery Polymer Zwitterions

Letteri, Rachel A.; Chalarca, Cristiam F. Santa; Bai, Ying; Hayward, Ryan C.; Emrick, Todd

doi:10.1002/adma.201702921

Cited by 27 publications

(36 citation statements)

References 45 publications

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“…Accordingly, polymers with all-carbon backbones are preferred, avoiding the risk of backbone hydrolysis [15,16,17]. For such vinyl and vinylidene polymers, it is generally assumed that polymers connecting the functional side groups by ester moieties to the backbone (such as poly((meth)acrylates)) are considerably more sensitive to hydrolysis than analogs bearing amide moieties (such as poly((meth)acrylamides)), and much more than derivatives of polystyrene or poly(diallylammonium) compounds [18,19,20,21]. Also, it is generally accepted that hydrolysis is accelerated by increasing temperature, as well as by acidic or basic conditions.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Long-Term Hydrolytic Behavior of Zwitterionic Polymethacrylates and Polymethacrylamides

2018

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The hydrolytic stability of polymers to be used for coatings in aqueous environments, for example, to confer anti-fouling properties, is crucial. However, long-term exposure studies on such polymers are virtually missing. In this context, we synthesized a set of nine polymers that are typically used for low-fouling coatings, comprising the well-established poly(oligoethylene glycol methylether methacrylate), poly(3-( N -2-methacryloylethyl- N,N -dimethyl) ammoniopropanesulfonate) (“sulfobetaine methacrylate”), and poly(3-( N -3-methacryamidopropyl- N,N -dimethyl)ammoniopropanesulfonate) (“sulfobetaine methacrylamide”) as well as a series of hitherto rarely studied polysulfabetaines, which had been suggested to be particularly hydrolysis-stable. Hydrolysis resistance upon extended storage in aqueous solution is followed by 1 H NMR at ambient temperature in various pH regimes. Whereas the monomers suffered slow (in PBS) to very fast hydrolysis (in 1 M NaOH), the polymers, including the polymethacrylates, proved to be highly stable. No degradation of the carboxyl ester or amide was observed after one year in PBS, 1 M HCl, or in sodium carbonate buffer of pH 10. This demonstrates their basic suitability for anti-fouling applications. Poly(sulfobetaine methacrylamide) proved even to be stable for one year in 1 M NaOH without any signs of degradation. The stability is ascribed to a steric shielding effect. The hemisulfate group in the polysulfabetaines, however, was found to be partially labile.

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Section: Introductionmentioning

confidence: 99%

Exploring the Long-Term Hydrolytic Behavior of Zwitterionic Polymethacrylates and Polymethacrylamides

2018

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“…With this technique, droplets can be generated with predictable sizes and compositions. Experiment performed in microfluidic device for the fabrication of zwitterion structure droplets has been reported by Emrick and co‐workers (Figure C) . In this work, they used a device which consists of two T‐shaped junctions and a Y‐junction.…”

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

“…Experiment performed in microfluidic device for the fabrication of zwitterion structure droplets has been reported by Emrick and co-workers ( Figure 2C). [77] In this work, they used a device which consists of two T-shaped junctions and a Y-junction. These two parts were used to form droplets and to mix the Small 2020, 16,1903940 Creation, mixing, incubation, sorting An integrated droplet-digital microfluidic system [103] Sorting Superhydrophobic interdigitated array chips [104] Floating Movable electrode biased with a high voltage [105] Mixing Open and closed digital microfluidic platforms [106] Coalescence, migrating Polypyrrole whelk-like arrays [107] Generation, transportation, splitting Ionic-surfactant-mediated electro-dewetting digital microfluidics [108] Magnetic Sorting Magnetophoretic sorting system [101] Splitting, dispensing, exchange, trapping, release, demulsification An integrated magnetic repulsion-actuated microfluidic system [111] Mixing, migrating, transport, release, coalescence Ferrofluid-containing liquid-infused porous surfaces [113] Transport, sorting, mixing A magnetic digital microfluidics platform [114] Shape evolution, splitting A device with hydrophobic surface under the magnetic field [115] Transport, splitting, motion Magnetic tubular microactuators [116] Motion, transport, fusion A deformable paramagnetic liquid substrate [117] Acoustic Coalescence A straight channel with a narrow beam surface acoustic wave [119] Splitting, steering A disposable parallel-type SAW-based acoustofluidic device [120] Gravity Transport, collision, fusion, mixing, stopping A gravity-actuated droplet microfluidics device [67] Movement, mixing Polydopamine microfluidic system [121] Trapping, exchange, transfer, fusion A microstructures device possesses microwell arrays and straight microchannel [122] Optical Motion A device with a single focused laser [124] Motion, patterned writing A device with photoelectric cooperative-responsive slippery surface [125] Sorting, dispensing Printed droplet microfluidics [126] Transportation, merging, splitting Light-driven flexible opto-electrowetting devices [127] Mixing, motion, coalescence A pyroelectrotr...…”

Section: T-junction Devices For the Fabrication Of Dropletsmentioning

confidence: 99%

Section: Flow-focusing Devices For the Fabrication Of Dropletsmentioning

confidence: 99%

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Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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Building Supracolloidal Fibers from Zwitterion‐Stabilized Adhesive Emulsions

Chalarca

Letteri

Perazzo

et al. 2018

Adv Funct Materials

Self Cite

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Oil-in-water droplets stabilized with polymer zwitterions (PZWs) exhibit salt-responsive aggregationdisaggregation behavior. In this paper, we describe a method to shape these droplets, starting from their aggregated state, into supracolloidal fibers by simply extruding them into aqueous media. The effect of salt concentration, in both the initial emulsion and the aqueous media, on the ability of the emulsions to form fibers is examined. After fiber formation, a transition from well-defined macroscopic fibers to non-interacting droplet dispersions can be triggered, simply by increasing the salt concentration of the aqueous environment. The inter-droplet energy of adhesion and emulsion rheology correlate qualitatively with salt concentration and thus impact the ability of the emulsions to be shaped by extrusion. The inter-droplet adhesion is dependent on both salt concentration and polymer composition, which allows tailoring of conditions to trigger fiber disaggregation. Finally, fibers with variable compositions along their length are prepared by sequential loading and extrusion of emulsions containing oil phases of differing densities.Received: ((will be filled in by the editorial staff))Revised: ((will be filled in by the editorial staff))

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Forming Sticky Droplets from Slippery Polymer Zwitterions

Cited by 27 publications

References 45 publications

Exploring the Long-Term Hydrolytic Behavior of Zwitterionic Polymethacrylates and Polymethacrylamides

Exploring the Long-Term Hydrolytic Behavior of Zwitterionic Polymethacrylates and Polymethacrylamides

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Building Supracolloidal Fibers from Zwitterion‐Stabilized Adhesive Emulsions

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