Miocene (ca. 18 Ma) subduction-related basalts and basaltic andesites from Monte Arcuentu, southern Sardinia, Italy, show a remarkable correlation between 87 Sr/ 86 Sr (from ~0.705 to ~0.711) over a small range of SiO 2 (~51-58 wt%) that contrasts with most other orogenic volcanic suites worldwide. New high-precision Pb and Hf isotope data help to constrain the petrogenesis of these rocks. The most primitive Monte Arcuentu rocks (MgO >8.5 wt%) were sourced from a mantle wedge metasomatized by melts derived from terrigenous sediment, likely derived from Archean terranes of northern Africa. This gave rise to magmas with high 87 Sr/ 86 Sr (0.705-0.709) and 207 Pb/ 204 Pb (15.65-15.67) with moderate εHf (-1 to +8) and εNd (-6 to +1), but it does not account for the full range of compositions observed. More evolved rocks (MgO <8.5 wt%) have higher 87 Sr/ 86 Sr (up to 0.711) and 207 Pb/ 204 Pb (up to 15.68), with εHf and εNd as low as-8 and-9, respectively. Mixing calculations suggest that evolved rocks with low Rb/Ba and low 206 Pb/ 204 Pb interacted with lower crust similar compositionally to that exposed today in Calabria, Italy, which was formerly in crustal continuity with Sardinia. High Rb/Ba and high 206 Pb/ 204 Pb magmas interacted with lithospheric mantle similar to that sampled by Italian lamproites. Partial melting of lower crustal and upper mantle lithologies was facilitated by the rapid extension, and subsequent passive mantle upwelling, that occurred as Sardinia drifted away from the European plate during the Oligo-Miocene (ca. 32-15 Ma). Fractional crystallization under these PT conditions involved olivine + clinopyroxene with little or no plagioclase, such that differentiation proceeded without significant increase in SiO 2. The Monte Arcuentu rocks provide insights into assimilation process in the lower crust and lithospheric mantle that may be obscured by upper crustal assimilation-fractional crystallization (AFC) processes in other orogenic suites.